EFFECTS OF EXERCISE ON THE CORONARY VASCULATURE

用仪器测定冠状动脉侧支循环发展的时间进程 将对冠脉闭塞的狗进行连续的铊扫描研究。 闭塞后，2天后用同位素进行第一次扫描。 在跑步机上跑步时注射。在注射后，动物将被 麻醉，允许扫描超过4小时，以便再灌流 可以观察到周期。然后每隔5-7天重复扫描一次，以测量 缺血面积的缩小。 利用犬左前降支闭塞和下腔静脉狭窄的模型，血流动力学，远端 冠脉内术后检查LCF压力和心肌血流量 硝苯地平注射剂。通过评估药物对远端LCFs的影响 压力和心肌流量，将确定是否存在盗血。

To determine the time course of coronary collateral development, instrumented dogs with coronary occlusions will be studied serially with thallium scanning. Following occlusion, the first scan is to be performed 2 days later with isotope injection during treadmill running. Following injection the animals will be anesthetized to permit scanning over a 4-hour period so that the reperfusion period can be observed. Then scans will be repeated every 5-7 days to measure the reduction in area of ischemia. Using the canine model of LAD occlusion and LCf stenosis, hemodynamics, distal LCf pressure, and myocardial blood flow will be examined following intracoronary Nifedipine injection. By evaluating the effect of the drug on distal LCf pressure and myocardial flow, the presence of steal will be determined.