CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
批准号:
6183392
负责人:
MICHAEL Victor COHEN
金额:
$20.36万
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-09-01 至 2002-08-31
关键词:
adenosine cardiac myocytes catecholamines chemoprevention cytoprotection dogs enzyme activity heart disorder heart pharmacology laboratory rabbit microdialysis myocardial ischemia /hypoxia phosphatase inhibitor phosphorylation polymerization protective chemical group protein kinase C protein tyrosine kinase protein tyrosine phosphatase species difference staurosporine stress proteins
中文摘要
描述(改编自申请人的摘要):本提案将
检验关于所提供的保护机制的几个新假设
通过预适应。由于提议的PKC的核心重要性
预适应的保护及其参与的争议
在较大的物种中,如狗和猪,PKC激活的要求
在对分离的犬心肌细胞进行预适应时,将确定
评估技术因素或真正的物种差异是否具有
到目前为止,还没有在狗身上证实PKC假说。近期
数据显示,酪氨酸激酶的激活也参与了
保护,这是下游的蛋白激酶C,从而形成一个激酶级联。
调查人员将测试几种酪氨酸的参与程度
在脑缺血和再灌注损伤中,激酶级联反应,尤其是p38 MAPK通路。
药物预适应。他们将进一步检验这一假设
这种保护途径终止于对蛋白磷酸酶的抑制。
随着构成磷酸化蛋白质的最终保存,
可能是细胞骨架元素。
英文摘要
DESCRIPTION (adapted from the applicant's abstract): This proposal will
test several new hypotheses concerning the mechanism of protection provided
by preconditioning. Because of the proposed central importance of PKC to
preconditioning's protection and the controversy surrounding its involvement
in larger species such as the dog and pig, the requirement of PKC activation
in preconditioning in isolated canine cardiomyocytes will be determined to
evaluate whether technical factors or true species differences have
heretofore prevented confirmation of the PKC hypothesis in dogs. Recent
data reveal that tyrosine kinase activation is also involved in the
protection, and that is downstream of PKC, thus forming a kinase cascade.
The investigators will test the involvement of several of the tyrosine
kinase cascades, especially the p38 MAPK pathway, in ischemic and
pharmacologic preconditioning. They will further test the hypothesis that
this pathway to protection terminates in inhibition of a protein phosphatase
with ultimate preservation of constitutively phosphorylated proteins,
possibly cytoskeletal elements.
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CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:6686005
-
项目类别:
-
资助金额:$25.55万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:2463138
-
项目类别:
-
资助金额:$18.63万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:6979789
-
项目类别:
-
资助金额:$24.95万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:2226939
-
项目类别:
-
资助金额:$16.99万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:2226938
-
项目类别:
-
资助金额:$16.0万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:2771358
-
项目类别:
-
资助金额:$19.19万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:6819233
-
项目类别:
-
资助金额:$25.55万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:6580201
-
项目类别:
-
资助金额:$25.55万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:6056263
-
项目类别:
-
资助金额:$19.77万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CATECHOLS AND ADENOSINE IN MYOCARDIAL PRECONDITIONING
-
批准号:3369626
-
项目类别:
-
资助金额:$17.57万
-
财政年份:1993
-
负责人:MICHAEL Victor COHEN
-
依托单位:
CORONARY COLLATERAL FUNCTION
-
批准号:3057139
-
项目类别:
-
资助金额:$0.83万
-
财政年份:1987
-
负责人:MICHAEL Victor COHEN
-
依托单位:
EFFECTS OF EXERCISE ON THE CORONARY VASCULATURE
-
批准号:3335455
-
项目类别:
-
资助金额:$21.64万
-
财政年份:1978
-
负责人:MICHAEL Victor COHEN
-
依托单位:
EFFECTS OF EXERCISE ON THE CORONARY VASCULATURE
-
批准号:3335454
-
项目类别:
-
资助金额:$0.96万
-
财政年份:1978
-
负责人:MICHAEL Victor COHEN
-
依托单位:
EFFECTS OF EXERCISE ON THE CORONARY VASCULATURE
-
批准号:3335449
-
项目类别:
-
资助金额:$27.82万
-
财政年份:1978
-
负责人:MICHAEL Victor COHEN
-
依托单位:
EFFECTS OF EXERCISE ON THE CORONARY VASCULATURE
-
批准号:3335452
-
项目类别:
-
资助金额:$17.11万
-
财政年份:1978
-
负责人:MICHAEL Victor COHEN
-
依托单位:
EFFECTS OF EXERCISE ON THE CORONARY VASCULATURE
-
批准号:3335450
-
项目类别:
-
资助金额:$15.56万
-
财政年份:1978
-
负责人:MICHAEL Victor COHEN
-
依托单位:
EFFECTS OF EXERCISE ON THE CORONARY VASCULATURE
-
批准号:3335453
-
项目类别:
-
资助金额:$21.23万
-
财政年份:1978
-
负责人:MICHAEL Victor COHEN
-
依托单位:
EFFECTS OF EXERCISE ON THE CORONARY VASCULATURE
-
批准号:3335451
-
项目类别:
-
资助金额:$19.92万
-
财政年份:1978
-
负责人:MICHAEL Victor COHEN
-
依托单位:
海外基金