OPERATIONAL MECHANISMS OF AIRWAY RECEPTORS

这项建议是为了继续我们关于喉部的工作 受体和这项工作的延伸到 严重缺乏的上呼吸道(咽、鼻) 在传入神经方面的知识。试验性的 方案(目标1)将研究喉部感受器的特性 对已知的物理和化学性质的刺激物做出反应 引起咳嗽和/或支气管收缩。另一项议定书(目标2) 将验证改变喉部反应的可能性 冷感受器通过改变局部灌流。局部炎症 过程可以改变受体的功能，因此相应的 条件反射。将使用相同的协议来确定 薄荷脑作为喉部冷感受器刺激剂的特异性。 如果有效，这种物质可以被用作研究 这些结尾的反射效应。实验方案 专为研究咽部(目标3)和鼻腔(目标4)而设计 感受器是基于我们之前在喉部和意志上的工作 确定在上呼吸道的这些区域中是否存在 压力、温度和肌肉收缩感知器。这 不同的信息很可能在 维持呼吸道通畅的机制。最后一个项目(目标5) 关注环甲肌在修改上颌骨中的作用 呼吸道阻力。这和可逆性瘫痪的使用 其他喉部肌肉，当动物自发呼吸时， 应该提供新的可靠证据。它的活动是这样的 在喉返神经的情况下肌肉有用或有害 瘫痪？

The proposal is for a continuation of our work on laryngeal receptors and an extension of this work to other regions of the upper airway (pharynx, nose) for which there is a substantial lack of knowledge in terms of afferent innervation. An experimental protocol (Aim #1) will study the properties of laryngeal receptors responding to irritant of physical and chemical nature known to cause cough and/or bronchoconstriction. Another protocol (Aim #2) will verify the possibility of changing the response of laryngeal cold receptors by changing the local perfusion. Local inflammatory processes could alter receptor function and thus the corresponding reflexes. The same protocol will be used to ascertain the specificity of menthol as a stimulant of laryngeal cold receptors. If effective this substance could be used as a tool to study the reflex effects of these endings. The experimental protocols designed for the study of pharyngeal (Aim #3) and nasal (Aim #4) receptors are based on our previous work on the larynx and will ascertain the presence in these areas of the upper airway of pressure, temperature and muscle contraction sensing endings. This fferent information is likely to play a significant role in the mechanisms preserving airway patency. The last project (Aim #5) concerns the role of the cricothyroid muscle in modifying upper airway resistance. The use of reversible paralysis of this and other laryngeal muscles, while the animal breathes spontaneously, should provide new and reliable evidence. Is the activity of this muscle useful or detrimental in cases of recurrent laryngeal nerve paralysis?