LONG-TERM EFFECTS OF ANABOLIC STEROIDS IN MICE

雄激素--合成类固醇的使用在男性中很普遍 这在女运动员中并不少见。而当 这种做法的直接副作用有相当好的记录， 对于长期的--即终生的--后果，我们几乎一无所知 滥用类固醇的嫌疑。这是一项揭露年轻成年男性和 雌性小鼠对雄激素合成代谢激素的耐受性调查 这种治疗在中老年的后果。具体来说， 从两个月大开始，CBF1雌雄小鼠都将被给予6 几个月来周期性暴露于高剂量或低剂量的“堆积” 四种常被滥用的类固醇的组合。一些动物将会是 在8个月、12个月或24个月大时被杀，以观察对身体的影响 特异体的组成、繁殖能力和发育 病理学。其他小鼠将在同样的三个年龄段进行测试 评估他们的自发活动、力量和耐力，以及 性行为和攻击性行为。这些特殊的特征是 之所以选择它们，是因为它们在某种程度上都依赖于组织 雄激素在正常男性体内的作用及其在男性中的缺失 正常的雌性。在这组实验中特别重要的是 仔细记录滥用类固醇对寿命的任何影响。

The use of androgenic-anabolic steroids is wide-spread among male athletes, and it is not uncommon among female athletes. While the immediate side effects of this practice are reasonably well documented, almost nothing is known about the long-term--i.e., lifetime--consequences of steroid abuse. This is a proposal to expose young adult male and female mice to androgenic-anabolic steroids and then survey the enduring consequences of this treatment in middle and old age. Specifically, starting at two months of age, CBF1 mice of both sexes will be given 6 months of cyclic exposure to either high or low doses of a "stacked" combination of four commonly-abused steroids. Some animals will be killed at 8, 12, or 24 months of age to look for effects on body composition, reproductive capability and the development of specific pathologies. Other mice will be tested at these same three ages to assess their spontaneous locomotor activity, strength and endurance, and sexual and aggressive behavior. These particular characteristics were chosen because they are all dependent to some degree on the organizing actions of androgen in normal males and the absence of these actions in normal females. Of particular importance in this set of experiments will be a careful documentation of any effect of steroid abuse on life span.