SYSTOLIC HYPERTENSION IN THE ELDERLY - II

对551名60岁以上的单纯收缩期高血压患者进行队列研究， 在1981年和1982年招募了一个试点研究，以测试一个 阶梯式护理药物治疗对健康影响的全面试验。 试点研究的资金将于1984年6月结束;虽然最初的 目标已经实现，几个重要的新的研究问题， 出现了，需要完成已经开始的所有工作。 拟议的研究有以下目标： 1.为了测试低剂量利尿剂治疗的安全性和有效性， 在没有β受体阻滞剂的情况下， 老人 具体来说，可以控制多大比例的患者 12.5 mg的氯噻酮，并添加美托洛尔， 氯噻酮改变血压控制水平或患病率 副作用吗 2.对一组老年孤立性脑血管病患者进行为期两年的研究， 收缩期高血压患者已被密切跟踪两年， 接受阶梯式护理治疗或安慰剂，以a）验证 并扩展发病率估计; B）改进方法 用于不良事件监测; c）扩展以下事件的发生率估计值 行为功能障碍;和d）完成开发和测试的 分布式数据系统 3.目的：分析和报告2002年12月至2004年12月间我院高血压病的调查结果， 老年人方案试点研究，发表科学发现和 临床试验技术的方法学进展。

A cohort of 551 persons over age 60 with isolated systolic hypertension was recruited in 1981 and 1982 for a pilot study to test the feasibility of a full scale trial of the effects of stepped care drug treatment on health. Funding for the pilot study will end in June 1984; although the initial goal has been achieved, several important new research questions have arisen, and there is the need for completing all the work that has begun. The proposed research has the following objectives: 1. To test the safety and efficacy of low dose diuretic treatment, with and without beta blocking drugs, in isolated systolic hypertension in the elderly. Specifically, what proportion of patients can be controlled with 12.5 mg of chorthalidone daily, and does the addition of metoprolol to chlorthalidone alter the level of blood pressure control or the prevalence of side effects? 2. To study for two added years a cohort of elderly patients with isolated systolic hypertension who have been followed closely for two years, receiving either stepped care treatment or placebo, in order to a) validate and extend the incidence estimates for morbidity; b) improve the methods for adverse event monitoring; c) extend the incidence estimates for behavioral dysfunction; and d) complete the development and testing of the distributed data system. 3. To analyze and report the results from the Systolic Hypertension in the Elderly Program pilot study, publishing the scientific findings and the methodological advances in clinical trial technology.