SYSTOLIC HYPERTENSION IN THE ELDERLY - II

551名60岁以上的单纯收缩期高血压患者的队列是 在1981年和1982年被招募进行试点研究，以测试 分级护理药物治疗对健康影响的全面试验。 试点研究的资金将于1984年6月结束；尽管最初的 目标已经实现，几个重要的新研究问题 已经出现，需要完成已经开始的所有工作。 拟议的研究有以下目标： 1.测试小剂量利尿剂治疗的安全性和有效性 在没有β-受体阻滞剂的情况下， 老年人。具体地说，有多大比例的患者可以通过 每天12.5毫克，并将美托洛尔加入 氯苯吡酮改变血压控制水平或患病率 有副作用吗？ 2.对老年孤独症患者队列进行两年以上的研究 已经被密切跟踪了两年的收缩期高血压患者， 接受分级护理治疗或安慰剂，以便a)验证 并延长发病率估计数；b)改进方法 用于不良事件监测；c)延长以下几年的发病率估计数 行为障碍；以及d)完成开发和测试 分布式数据系统。 3.分析和报告高血压患者的收缩期高血压结果 老年人计划试点研究，发表科学发现和 临床试验技术的方法学进展。

A cohort of 551 persons over age 60 with isolated systolic hypertension was recruited in 1981 and 1982 for a pilot study to test the feasibility of a full scale trial of the effects of stepped care drug treatment on health. Funding for the pilot study will end in June 1984; although the initial goal has been achieved, several important new research questions have arisen, and there is the need for completing all the work that has begun. The proposed research has the following objectives: 1. To test the safety and efficacy of low dose diuretic treatment, with and without beta blocking drugs, in isolated systolic hypertension in the elderly. Specifically, what proportion of patients can be controlled with 12.5 mg of chorthalidone daily, and does the addition of metoprolol to chlorthalidone alter the level of blood pressure control or the prevalence of side effects? 2. To study for two added years a cohort of elderly patients with isolated systolic hypertension who have been followed closely for two years, receiving either stepped care treatment or placebo, in order to a) validate and extend the incidence estimates for morbidity; b) improve the methods for adverse event monitoring; c) extend the incidence estimates for behavioral dysfunction; and d) complete the development and testing of the distributed data system. 3. To analyze and report the results from the Systolic Hypertension in the Elderly Program pilot study, publishing the scientific findings and the methodological advances in clinical trial technology.