REGULATION OF SKIN BLOOD FLOW IN MAN

人体皮肤血流的调节既伴随着反射，也伴随着 地方机制。神经控制不仅源于体温调节 反射，但也来自非体温调节反射，如 与运动和血压调节有关。地方机制 包括与局部皮肤级别相关联的重要组件 血流测量部位的温度。这个项目是一个 我们继续探索对这一区域的监管 当这些控制来源相互竞争时的循环 其他人或正在协调行动。将继续把主要重点放在 论运动中皮肤血流量的调节 温度调节和非温度调节之间的内在竞争 条件反射。本提案涉及的具体问题包括(A)是否 皮肤血流量或出汗率对运动的反应更依赖于 强烈依赖于运动中涉及的肌肉质量，即特定的肌肉 团体，还是关于运动模式(等长与动态)？(B)是否 皮肤血管系统对血管紧张素转换酶开始和延续的反应 动态运动还是等长运动取决于运动水平？(C)可以 定义最大皮肤血流量？(D)动脉闭塞在 静脉闭塞体积描记术中的腕部被腕部静脉取代 遮挡？(E)强大的皮肤血管收缩反应能否 人体的跳水反射可被局部或全身减弱或消除 体温过高？(F)对皮肤血流量进行激光多普勒测量 充分遵循体积描记测量，当皮肤 血管收缩？ 对这些问题的回答将大大扩展我们的知识 关于这一流通的控制，并应为 了解如何在疾病状态下修改这种控制以及 提供一个评估热应激的影响和风险的理论基础 心血管疾病患者的锻炼。

Regulation of skin blood flow in man is accompanied by both reflex and local mechanisms. Neural control derives not only from thermoregulatory reflexes, but also from non-thermoregulatory reflexes, such as those associated with exercise and blood pressure regulation. Local mechanisms include an important component associated with the level of local skin temperature at the site of blood flow measurement. This project is a continuation of our exploration into the regulation of this regional circulation when these sources of control are in competition with each other or are acting in concert. Major emphasis will continue to be placed on the regulation of skin blood flow during exercise, in which there is a built-in competition between thermoregulatory and non-thermoregulatory reflexes. Specific questions addressed in this proposal include (a) does the response of skin blood flow or of sweat rate to exercise depend more strongly on the muscle mass involved in the exercise, the specific muscle group, or on the mode of exercise (isometric versus dynamic)? (b) is the response of the cutaneous vasculature to the onset and continuation of dynamic or isometric exercise dependent on the level of exercise? (c) can a maximal skin blood flow be defined? (d) can the arterial occlusion at the wrist in venous occlusion plethysmography be replaced by wrist venous occlusion? (e) can the potent cutaneous vasoconstrictor response to the diving reflex in man be attenuated or abolished by local or whole body hyperthermia? (f) Do laser-doppler measurements of skin blood flow adequately follow plethysmographic measurements when the skin is vasoconstricted? Answers to these questions will substantially extend our knowledge regarding the control of this circulation and should set the stage for understanding how such control is modified in disease states as well as offer a rationale by which to assess the impact and risk of heat stress and exercise of patients with cardiovascular disease.