OPERATIONAL MECHANISMS OF AIRWAY RECEPTORS

已知位置的呼吸道受体的循环可达性将是 研究将能够改变其活性的物质注入到 全身(左心房)或肺循环(右心房)。除了 对普遍接受的暗示或多或少的标准的验证 肺内受体的周围性定位 通过肺循环或体循环优先进入 这项研究将表明哪种血液(混合静脉或动脉)更多 任何特定位置的受体都可以访问。此信息具有 生理相关性考虑到几种物质能够影响 其中一些结局在人类的血液中有不同的浓度 肺部和全身循环。 我们将启动一项肺内缓慢适应能力的研究 产生与肺形状有关的信号的受体。对于任何给定的 容量和/或经肺压力，肺可有不同 构型及其缓慢适应的伸展感受器可能与此有关 提供给中央情报局的信息。

The circulatory accessibility of airways receptors of known location will be studied injecting substances capable of changing their activity either into the systemic (left artium) or the pulmonary circulation (right atrium). Besides the verification of the widely accepted criterion of implying a more or less peripheral location of the intrapulmonary receptors on the basis of their preferential accessibility by either the pulmonary or the systemic circulation this study will indicate which blood (mixed venous or arterial) is more accessible to receptors of any particular location. This information has physiological relevance considering that several substances capable of affecting some of these endings have a different concentration in the blood of the pulmonary and systemic circulations. We will initiate a study of the capability of intrapulmonary slowly adapting receptors to originate signals related to the shape of the lung. For any given volume and/or transpulmonary pressure, the lung can have different configuarations and its slowly adapting stretch receptors could relate this information to the C.N.S.