PREVENTION OF HIGH BLOOD PRESSURE IN CHILDREN

血压（BP）变化和BP升高的个体差异可能 部分原因是调节BP和BP的机制不同， 反应性 该项目有两个相关组成部分：1）继续 血压、体重、身高、体脂分布的纵向评估， 在817名每半年检查一次的受试者中， 自1978年以来;和2）比较“高风险”受试者组（顶部 连续三次测量收缩压的五分位数）， 选择对照组，探讨血浆 胰岛素和（BP）以及BP反应性作为肥胖、脂肪 分布、儿茶酚胺浓度和钠通量。 拟议 研究将重新检查817名年龄在18-21岁之间的健康男性和女性， 自1978年以来，她一直参与明尼阿波利斯儿童BP研究。 我们将 评估从儿童到青年血压变化的纵向预测因素 成年 体细胞生长、体脂分布、亲本 血压与肥胖有关，而几种健康习惯和行为对血压的改变也会 根据过去12年来采取的反复措施估计。 的 本研究的第二部分将评估 胰岛素和BP和BP反应性在一组有风险的受试者中 原发性高血压和对照组。 我们将定量葡萄糖 和胰岛素（空腹和葡萄糖负荷后）， 肾上腺素和去甲肾上腺素以及钠在红血中的转运 细胞膜，以更好地研究它们与BP的复杂相互关系。 肥胖、脂肪分布、体力活动和其他方面的差异 分析中将考虑协变量。 这项研究应 提供有价值的洞察机制，通过生理和 生物行为因素相互作用以影响血压调节。

Individual differences in blood pressure (BP) change and BP elevation may be due in part to differences in the mechanisms regulating BP and BP reactivity. This project has two related components; 1) to continue longitudinal assessments of BP, body weight, height body fat distribution, etc, in a cohort of 817 subjects who have been examined semi-annually since 1978; and 2) to compare a "high risk" group of subjects (top quintile of systolic BP on three consecutive occasions) to a randomly selected comparison group to explore the relationships between plasma insulin and (BP) and BP reactivity as a function of obesity, fat distribution, catecholamine concentrations, and sodium flux. The proposed study will reexamine 817 healthy men and women aged 18-21 years who have participated in the Minneapolis Children's BP Study since 1978. We will assess the longitudinal predictors of BP change from childhood to young adulthood. The effects of somatic growth, body fat distribution, parental BP and obesity, and several health habits and behaviors on BP change will be estimated from repeated measures taken over the last 12 years. The second component of this study will evaluate the association between insulin and BP and BP reactivity in a group of subjects at risk for essential hypertension and a comparison group. We will quantitate glucose and insulin (fasting and after a glucose load), serum concentrations of epinephrine and norepinephrine, and sodium transport across the red blood cell membrane to better study their complex interrelationships with BP. Differences in obesity, fat distribution, physical activity and other covariates will be taken into account in the analyses. This study should provide valuable insight into mechanisms through which physiologic and biobehavioral factors interact to effect blood pressure regulation.