Novel biomimetic vascular biomaterials using extracellular matrix molecules

目前迫切需要可生物降解的功能性生物材料来支持内皮细胞相互作用和血管再生。缺乏足够的血管再生是将生物材料发展转化为临床、诊断和研究应用的最大障碍。该项目旨在通过开发模拟血管生态位细胞外基质的新型生物材料平台来解决这一需求。我们计划利用独特的细胞外基质结构域和生物打印技术来控制和引导内皮细胞的功能。因此，我们可以为血管生物学和生物工程的知识库做出贡献，为未来的血管材料奠定基础。

There is currently a pressing, unmet need for biodegradable, functional biomaterials that support endothelial cell interactions and vascular regeneration. Lack of sufficient vascular regeneration is the biggest obstacle in translating advances in biomaterials development to clinical, diagnostic and research applications. This project aims to address this need by developing novel biomaterial platforms that mimic the extracellular matrix of the vascular niche. We plan to utilise unique extracellular matrix domains and bioprinting techniques to control and guide endothelial cell functions. We could thus contribute to the knowledge base in vascular biology and bioengineering, forming the basis for vascular materials of the future.