LONG-TERM EXERCISE INTERVENTION IN CYSTIC FIBROSIS

囊性纤维化是最常见的遗传性寿命缩短 白色人群中的疾病，其特征是进行性 肺功能和运动耐量的丧失。 我们有 以前的研究表明，锻炼计划可以增加健康， 这些患者，但对肺功能无明显影响。 其他人表现出肺功能的改善与活动 计划，但没有检查健康的病人囊性 纤维化 还没有研究考察过活动 项目可能对这些患者的健康质量产生的影响， 也没有适当控制的长期研究。 我们 计划制定一项为期两年的家庭活动计划， 大大提高患者的习惯性活动水平。 行为医学技术将用于促进遵守 这两年的计划。 将随机分配50名患者 50名患者参加非运动项目， 对照组 我们将研究该计划对 肺功能、运动耐量和健康质量 治疗组与对照组相比。 我们还将 确定身体活动之间是否存在任何关系（如 通过两个活动监测器和活动调查进行量化）， 肺功能，心肺功能测试和良好的质量- 存在

Cystic fibrosis is the most common inherited life-shortening disease among white populations and is characterized by progressive loss of pulmonary function and exercise tolerance. We have previously shown that exercise programs can increase fitness in these patients, but without apparent effect on lung function. Others have shown improvement in pulmonary function with activity programs but have not examined fitness in patients with cystic fibrosis. No studies have examined the effect that activity programs may have on the quality of well-being in these patients, nor have there ben appropriately controlled long-term studies. We plan to institute a two year at-home activity program which will substantially increase the patients level of habitual activity. Behavioral medicine techniques will be used to promote compliance to this two year program. Fifty patients will be randomly assigned to the activity program and fifty patients to a non-exercise control group. We will examine the effects of this program on pulmonary function, exercise tolerance and quality of well-being of the treatment group compared to the control group. We will also determine if any relationship exists among physical activity (as quantified by two activity monitors and activity surveys) and pulmonary function, cardiopulmonary testing and quality of well- being.