LONG-TERM EXERCISE INTERVENTION IN CYSTIC FIBROSIS

囊性纤维化是最常见的遗传性缩短寿命的疾病 白人人群中的疾病，其特点是进行性 肺功能和运动耐量的丧失。我们有 先前的研究表明，锻炼计划可以在 这些患者，但对肺功能无明显影响。 其他人则表现出随着活动而肺功能的改善。 计划，但没有检查囊肿症患者的健康状况 纤维化症。还没有研究检验这种活动的影响 这些项目可能会对这些患者的健康质量产生影响， 本也没有适当地控制长期研究。我们 计划实施一项为期两年的居家活动计划，该计划将 大幅度提高患者的习惯性活动水平。 将使用行为医学技术来促进遵从性 参加这个为期两年的项目。将随机分配50名患者 对活动计划和50名患者进行非锻炼 对照组。我们将考察这一计划对 肺功能、运动耐量与幸福感质量 治疗组与对照组比较。我们还将 确定体力活动之间是否存在任何关系(如 由两个活动监测和活动调查量化)和 肺功能、心肺测试和井水质量 是存在的。

Cystic fibrosis is the most common inherited life-shortening disease among white populations and is characterized by progressive loss of pulmonary function and exercise tolerance. We have previously shown that exercise programs can increase fitness in these patients, but without apparent effect on lung function. Others have shown improvement in pulmonary function with activity programs but have not examined fitness in patients with cystic fibrosis. No studies have examined the effect that activity programs may have on the quality of well-being in these patients, nor have there ben appropriately controlled long-term studies. We plan to institute a two year at-home activity program which will substantially increase the patients level of habitual activity. Behavioral medicine techniques will be used to promote compliance to this two year program. Fifty patients will be randomly assigned to the activity program and fifty patients to a non-exercise control group. We will examine the effects of this program on pulmonary function, exercise tolerance and quality of well-being of the treatment group compared to the control group. We will also determine if any relationship exists among physical activity (as quantified by two activity monitors and activity surveys) and pulmonary function, cardiopulmonary testing and quality of well- being.