Insulin transport into the central nervous system

本项目旨在了解外周胰岛素进入中枢神经系统的运输及其如何维持能量平衡。胰岛素对周围和中枢神经系统的正常生理功能至关重要，但在某些情况下，包括高脂肪饮食，会减少大脑中的胰岛素信号。本项目研究胰岛素转运到中枢神经系统的机制，并可能提高我们对血脑屏障胰岛素转运和功能障碍的理解。

This project aims to understand transportation of peripheral insulin into the central nervous system and how it maintains energy balance. Insulin is essential for normal physiological functioning in the periphery and central nervous system, but some circumstances, including high-fat diets, reduce insulin signalling in the brain. This project examines the mechanisms of insulin transport into the central nervous system, and may improve our understanding of blood brain barrier insulin transport and dysfunction.