CONTINUED UTILIZATION OF THE MILIS DATA BASE

拟议的申请是为了继续支持对 CT大小限制的多中心研究（MILIS）数据 基地 MILIS试验是一项合作、随机、对照研究 测试透明质酸酶和普萘洛尔在早期 急性心肌梗死的治疗。 共有9，450名患者 筛选试验，985名患者随机分为五个主要的 医院的 随访于1984年7月1日结束，平均随访时间为 31.8个月 该试验涉及广泛的临床和实验室 在急性期根据标准方案收集的监测评价 事件包括常规实验室检查数据、基线病史、系列 酶、锝-99m焦磷酸盐心肌血样采集 多门控放射性核素心室造影术，标准12导联 ECG、心前区ECG标测、心电向量图和24小时霍尔特 录音. 此外，还为所有患者安排了随访 以及随后对健康状况的确定 每隔六个月通过电话了解一次状况。 病理检查 死亡患者的心脏也被切除。 RTI（试验数据协调中心），哈佛医学院 （试验的临床协调中心）、NHLBI和几个MILIS 调查人员正在分析开发的广泛数据库 从MILIS审判。 这包括以下终点结果的分析： 透明质酸酶和大量数据库研究。 41项数据库研究 已获得MILIS数据库委员会的批准， 9篇出版物和20多篇演讲。 预计剩余的终点研究和8-12项额外的 出版物将于1986年7月14日完成。 这 还剩下大约20项正在进行的经批准的数据库研究有待完成。 几位MILIS临床研究者同意参加 建议的补助金有进一步的研究课题，可利用 MILIS数据库。 这包括来自哈佛小组的10项研究。 支持 将确保继续分析军事信息系统数据库， 将完成数据库研究以及其他几项研究 NHLBI和MILIS调查人员感兴趣的东西

The proposed application is for continued support for analysis of the Multicenter Investigation of the Limitation of Infarct Size (MILIS) data base. The MILIS trial was a collaborative, randomized, controlled study testing the efficacy of hyaluronidase and propranolol in the early treatment of acute myocardial infarction. A total of 9,450 patients were screened for the trial and 985 patients were randomized at five major hospitals. Follow-up ended on July 1, 1984 with a mean follow-up time of 31.8 months. The trial involved extensive clinical and laboratory monitoring evaluations collected under a standard protocol during the acute event including routine laboratory test data, baseline histories, serial blood sampling for enzymes, technetium-99m pyrophosphate myocardial scintigraphy, multigated radionuclide ventriculography, standard 12-lead ECGs, precordial ECG mapping, vectorcardiograms and 24-hour Holter recordings. In addition, follow-up visits were scheduled for all patients at three and six months as well as subsequent determination of health status at six-month intervals by phone. Pathological examination of the hearts of patients who died was also performed. RTI (Data Coordinating Center for the trial), Harvard Medical School (Clinical Coordinating Center for the trial), NHLBI and several MILIS investigators are involved in analyzing the extensive data base developed from the MILIS trial. This includes analyses of endpoint results for hyaluronidase and numerous data bank studies. Forty-one data bank studies have been approved by the MILIS Data Bank Committee which have resulted in 9 publications and over 20 presentations. It is anticipated that the remaining endpoint studies and 8-12 additional publications will have been completed by the end of July 14, 1986. This leaves approximately 20 active approved data bank studies to be completed. Several MILIS clinical investigators who have agreed to participate in the proposed grant have further research topics which may be explored using the MILIS data base. This includes 10 studies from the Harvard group. Support would ensure continued analysis of the MILIS data base so that the approved data bank studies will be completed as well as several additional studies of interest to NHLBI and the MILIS investigators.