FAMILIAL HYPERTENSION & BIRACIAL CV REACTIVITY IN YOUTH

原发性高血压（EH）是美国的一个主要健康问题; 这在黑人中尤其普遍。 试图说明 对于EH的种族差异， 方法，其中变量，如肥胖，吸烟，饮酒， 久坐不动的生活方式、饮食史和遗传被认为是相关的 这一差异。 人们普遍认为， 风险因素是任何预防EH计划的主要目标。 一个 越来越多的证据支持心血管疾病 反应性是一个标志，也可能是一个重要的风险因素， 在EH的进化过程中。 到目前为止，只有有限的数据， 解决心血管反应性对心理和/或 黑人和白人之间的身体对抗 我们已经证明 心血管对生理和心理压力的反应确实不同 健康的黑人儿童和白色儿童之间的差异。 本研究的目的是在2（受试者种族）x 2（性别）中评估 的受试者）× 3（父母高血压状态）设计如下：1） 对压力刺激的反应差异：心理，身体和 “日常生活”，2）A/B型行为的组成部分的影响 3）心血管反应性与代谢的关系， 酶和饮食测量，包括血浆肾素、Ca++、Na+ 摄入量和排泄量以及红细胞Na+ K+-ATP酶; Na+、K+、Ca++、NaCl和安慰剂的负荷对反应性、代谢性 和酶的测量。 这项研究的结果可能证明新的诊断方法的发展是合理的。 简单，非侵入性评估潜在重要的 危险因素 这些新的程序可以纳入一个计划， 预防性心脏病筛查和可能的前瞻性干预 问题研究

Essential hypertension (EH) is a major health concern in the United States; it is especially prevalent in the black population. Attempts to account for the racial difference in EH have tried to apply the risk factor approach, in which variables such as obesity, smoking, alcohol intake, sedentary lifestyle, dietary history, and heredity are presumed to relate directly to this difference. It is generally agreed that the reduction of risk factors is the major goal of any program for the prevention of EH. An increasing body of evidence supports the concept that cardiovascular reactivity is a marker, and possibly an important risk factor in its own right, in the evolution of EH. To date, there are limited data which address differences in cardiovascular reactivity to psychologic and/or physical challenge between blacks and whites. We have demonstrated that cardiovascular reactivity to physical and psychologic stress does differ between groups of healthy black children and white children. The objectives of this study are to assess in a 2(race of subject) x 2(sex of subject) x 3(parental hypertension status) design the following: 1) differences in responses to stressful stimuli: psychologic, physical, and "everyday life," 2) effects of the components of the Type A/B behavior dimension, 3) relation of cardiovascular reactivity to metabolic, enzymatic, and dietary measurements, including plasma renin, Ca++, Na+ intake and excretion, and erythrocyte Na+ K+-ATPase, 4) effects of dietary loading of Na+, K+, Ca++, NaCl, and placebo upon the reactivity, metabolic, and enzymatic measurements. The results of this study may justify the development of new diagnostic procedures for the simple, non-invasive assessment of potentially important risk factors. These new procedures could be incorporated into a program of preventive cardiology screening and possibly prospective intervention studies.