TRICYCLIC ANTIDEPRESSANTS AND COGNITIVE TOXICITY

全身性急、慢性三环类抗抑郁药(TCA)疗效观察 治疗和停药的评估是根据对 生理、心理和认知功能。抑郁的门诊患者 被随机分配到治疗三个月的高或低 抗胆碱能TCA，重复评估，然后随机到 继续或停止治疗6个月以上。 特别是对症状和生理的广泛评估 认知功能以基线和3个月为间隔进行测试 每周和每两周进行一次临时访问，以比较TCA的影响和 评估纵向疗程。主要分析将： (1)与年龄、抑郁程度、抑郁类型、抗胆碱能药物有关 活动，以及对认知功能的特异性TCA；(2)评估生理， 心理和认知功能作为质量的描述符 缓解和复发的预测因素。

Effects of systematic acute and chronic tricyclic antidepressant (TCA) treatment and treatment withdrawal are assessed in terms of effects on physiologic, psychologic, and cognitive function. Depressed outpatients are assigned randomly to treatment for three months on a high or low anticholinergic TCA, evaluated repeatedly, and then randomized to continuation or discontinuation treatment for six additional months. Particularly extensive assessments of symptomatology and physiologic and cognitive function are made at baseline and 3-month intervals in addition to weekly and biweekly interim visits in order to compare TCA effects and to evaluate longitudinal course of treatment. Principal analyses will: (1) relate age, degree and type of depression, drug anticholinergic activity, and specific TCA to cognitive function; (2) assess physiological, psychological, and cognitive function as descriptors of quality of remission and predictors of relapse.