ANTIDEPRESSANTS AND MONOAMINE RECEPTORS AND RESPONSES

这项研究的目的是为了更好地了解 抗抑郁药治疗的药理作用，当给药超过 时间，对中枢生物胺神经元系统。 这将预期 导致对情感疾病生物学的更好理解， 改善这些疾病的治疗。 特别是，我们打算研究 是否长期治疗大鼠与各种建立和更新 抗抑郁治疗会导致β-肾上腺素能受体的发育 次敏感性 β-肾上腺素能受体将使用 放射性β-肾上腺素能拮抗剂（减）3 H-二氢阿烯洛尔（3 H-DHA）。 在 此外，还计划进行一些实验，以提供有关 抗抑郁药诱导的中枢神经系统疾病的临床相关性 β-肾上腺素能受体不敏感 这种类型的扩展 调查将是我们使用的3 H-5羟色胺（血清素）标记 中枢多巴胺能受体，以研究重复的影响， 用不同类型的精神药物对这些受体进行治疗。 松果体将被用来衡量抗抑郁治疗的效果 对肾上腺素能反应的影响。 儿茶酚胺会 对急性或慢性给药的大鼠进行外源性给药， 抗抑郁药和腺苷酸浓度 （环磷酸腺苷）在松果体测量。 此外，急性能力 用去甲基丙咪嗪长期治疗大鼠以改变肾上腺素能 内源性释放去甲肾上腺素引起的松果体反应 将研究来自支配松果体的交感神经。

The goal of this research is to provide a better understanding of the pharmacological effects of antidepressant treatments, when administered over time, on central biogenic amine neuronal systems. This would be expected to lead to an improved understanding of the biology of affective illnesses and toward improved treatment of these illnesses. In particular, we intend to study whether chronic treatment of rats with a variety of established and newer antidepressant treatments causes the development of beta-adrenergic receptor subsensitivity. Beta-adrenergic receptors will be studied with the use of the radioactive beta-adrenergic antagonist (minus)3H-dihydroalrenolol (3H-DHA). In addition, experiments are planned that should provide some information on the clinical relevance of the antidepressant drug-induced development of central beta-adrenergic receptor subsensitivity. An expansion of this type of investigation will be our use of 3H-5hydroxytryptamine (serotonin) to label central serotonergic receptors so as to investigate the effects of repeated treatment of rats with different types of psychotropic drugs on these receptors. The pineal gland will be used to measure the effect of antidepressant treatments on adrenergic responsiveness both in vivo and in vitro. Catecholamines will be administered exogenously to rats treated either acutely or chronically with antidepressant drugs and the concentration of adenosine 3',5' monophosphate (cyclic AMP) in the pineal gland measured. In addition, the ability of acute and chronic treatment of rats with desmethylimipramine to modify adrenergic responses in the pineal gland caused by norepinephrine released endogenously from the sympathetic nerve innervating the pineal gland will be studied.