PHYSIOLOGY OF RECOVERY FROM INTERSTITIAL PULMONARY EDEMA

这些拟议调查的主要目的是 确定从间质恢复的时间进程 肺水肿。几条清关路线将是 量化但主要强调的是新发现的 纵隔清除途径。我们的具体目标是：1) 确定高水平或高水平的间质水肿液 从肺中清除低浓度的蛋白质，以测试 假设高蛋白渗透压的水肿液，由 限制血液的再吸收，清除的速度会慢于 低蛋白渗透压所致的水肿；2)量化途径 不同形式的间质液体清除 肺水肿，以检验纵隔的假设 途径是间质水肿清除的主要途径； 3)量化支气管血管周围间质的作用 肺水肿至肺淋巴流量，以检验存在的假设 淋巴系统几乎没有清除。我们获得的数据 将定量地阐明肺的不同途径的作用 间质液体和蛋白质流。这将给科学家们带来一个 更好地理解各种形式的总体病理生理学 并将给医生带来更好的 从自然历史的角度理解将会发生什么 从浮肿中恢复，这将使他们能够设计新的 可以提高清除率的治疗方法。我们会做一些实验 三种(绵羊、山羊、兔子)；每一种都是特别需要的 为特定问题提供最佳解决方案，以及 检验结果的一般种间适用性。

The main objective of these proposed investigations is to determine the time course of recovery from interstitial pulmonary edema. The several routes of clearance will be quantified but the main emphasize will on the newly-discovered mediastinal clearance pathway. Our specific aims are: 1) to determine the rate at which interstitial edema liquid of high or low protein concentration is cleared from the lung, to test the hypothesis that edema liquid of high protein osmotic pressure, by limiting blood reabsorption, will be cleared less quickly than will edema of low protein osmotic pressure; 2) to quantify the routes of interstitial liquid clearance in various forms of interstitial pulmonary edema, to test the hypothesis that the mediastinal pathway is the principal route of interstitial edema clearance; and 3) to quantify the contribution of peribronchovascular interstitial edema to lung lymph flow, to test the hypothesis that there is little clearance via the lymphatic system. The data we obtain will clarify, quantitatively, the role of various pathways of lung interstitial liquid and protein flow. This will give scientists a better understanding of the total pathophysiology of various forms of pulmonary edema and will give physicians a better understanding of what to expect in terms of the natural history of recovery from edema, which will enable them to design new treatments that will enhance clearance. Experiments will be done in three species (sheep, goat, rabbit); each specifically necessary to provide the best solution to a particular problem, as well as to test the general interspecies applicability of the results.