X-RAY BACKSCATTER IMAGING OF VENTRICULAR ACTIVATION

缺血性心脏病和心肌病是主要的心脏病 导致美国成年人猝死的疾病。 室性心动过速变性常导致死亡 变成纤维性颤动 手术和经导管消融治疗 已经从这种心律失常的治疗中出现。 这些 治疗需要心室的激活标测 在手术切除或消融之前的异常电通路。 术中标测是目前的首选方法， 找到这样的路径。 术中标测程序， 然而，这些方法是复杂、耗时和侵入性。 有，作为 因此，一个相当大的激励，以尽量减少其程度， 必要性。 一种非侵入性标测技术， 手术前异常的电通路， 相当大的价值。 该提案的目的是发展 这种技术基于对反向散射的X-射线的检测， 射线 反向散射X射线将用于创建高精度 自由壁的位移、速度和加速度图 心脏 这些高时间分辨率的地图将被用于 定位异位电活动的位置 反向散射 标测程序是非侵入性的，既不需要切割， 注射，并使用最低水平的辐射。 建议的具体目标是：a）制定必要的 用于测量高精度壁动态的硬件和软件 使用辐射反向散射测量技术，以及B） 使用该硬件和软件进行激活映射研究， 起搏的室性心律失常犬模型。 的最终目标 该建议是一种非侵入性的高精度激活标测 适用于启动人体试验的技术。

Ischemic heart disease and cardiomyopathy are major cardiac disorders leading to sudden death in adults in the United States. Death usually results from ventricular tachycardia degenerating into fibrillation. Surgical and trans-catheter ablation therapies have emerged from the treatment of such arrhythmias. These treatments require activation mapping of the ventricles to locate aberrant electrical pathways prior to surgical excision or ablation. Intraoperative mapping is currently the method of choice for locating such pathways. Intraoperative mapping procedures, however, are complex, time consuming, and invasive. There is, as a result, a considerable incentive to minimize their extent and necessity. A non-invasive mapping technique capable of locating aberrant electrical pathways prior to surgery, would be of considerable value. The purpose of this proposal is to develop such a technique based upon the detection of backscattered x- rays. Backscattered x-rays will be used to create high precision displacement, velocity and acceleration maps of the free walls of the heart. These high temporal resolution maps will then be used to locate site of electrical ectopic activity. The backscatter mapping procedure is non-invasive, requires neither cutdowns nor injections, and uses minimal levels of radiation. The specific aims of the proposal are: a) to develop the necessary hardware and software for measuring high precision wall dynamics using a radiation backscatter measurement technique, and b) to use that hardware and software for activation mapping studies in a paced canine model of ventricular arrhythmias. The end goal of this proposal is a non-invasive high precision activation mapping technique suitable for initiating testing in humans.