RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

女性患冠心病的风险低于男性。 这 是由于1）性激素，2）胰岛素 敏感性; 3）环境因素。 多囊卵巢 (PCO)综合征具有特征，包括不排卵， 高雄激素血症和胰岛素抵抗，这表明男性风险因素 profile. 在拟议的研究中，我们调查的假设，妇女 占女性人口5%的PCO患者， CHD然后是非PCO女性。 尽管人们对研究 PCO的内分泌学和病理生理学， PCO综合征女性患者的长期随访队列数据。 在 建议的研究，我们将跟踪和跟进，通过电话采访，600 通过1970-86年的办公室记录确定患有PCO的妇女。 我们将 然后进行一项横断面研究，以评估生殖，激素， 与对照组相比， 控制人口。 预计成功追踪和 征聘工作将查明大约390个案件， 年龄匹配的邻居对照。 评价将由一个办公室组成， 访视以确定：总胆固醇、甘油三酯、HDL胆固醇， 空腹和2小时血糖和胰岛素、血压、终生吸烟 吸烟、饮酒、生育史、终生用药情况， PCO家族史和血清激素浓度。 在这个 评价，医生根据病史诊断PCO，体格检查 将进行检查和激素研究。 此外，关于 怀孕次数、活产次数、月经史，以及 将获得手术或自然绝经史。 妇女 甲状腺、肾上腺或垂体疾病的证据将被排除。 病例与对照组的比较将包括以下方面差异的检验： 已知的冠心病风险因素：激素，血压，脂蛋白脂质， 葡萄糖和胰岛素。 体重指数，体重，饮食，运动，酒精， 吸烟、冠心病史、血压和生育史 将作为独立变量进行检查，这些变量可能解释 冠心病危险因素。 PCO对风险因素的估计影响为 调整了重要的独立变量。 总之，我们的研究将 提供资料，说明患有PCO的妇女是否有更高的发病率， 已知的冠心病风险因素，而不是匹配的非PCO女性， 关于这些妇女随后健康状况的资料。 的结果 这项研究将为多中心研究提供可行性， 患PCO的妇女患心脏病和其他疾病的风险。

The risk of coronary heart disease (CHD) is lower in women than men. This has been attributed to differences in 1) sex hormones, 2) insulin sensitivity and 3) environmental factors. Women with Polycystic Ovary (PCO) syndrome have characteristics, including anovulation, hyperandrogenism and insulin resistance, which suggests a male risk factor profile. In the proposed study, we investigate the hypothesis that women with PCO, who comprise 5% of the female population, are at greater risk of CHD then non-PCO women. Although there has been great interest in studying the endocrinology and pathophysiology of PCO, there are relatively little data on long term follow-up cohorts of women with PCO syndrome. In the proposed study we will trace and follow-up, via telephone interview, 600 women with PCO identified through office records from 1970-86. We will then conduct a cross-sectional study to assess reproductive, hormonal, and other CHD risk factors in this group of women with PCO compared with a control population. It is anticipated that successful tracing and recruitment will result in ascertainment of approximately 390 cases and 390 age-matched neighborhood controls. Evaluation will consist of an office visit to determine: total cholesterol, triglycerides, HDL cholesterol, fasting and 2 hour glucose and insulin, blood pressure, lifetime cigarette smoking, alcohol intake, reproductive history, lifetime medication usage, family history of PCO, and serum hormone concentrations. At this evaluation, a physician diagnosis of PCO from history, physical examination, and hormone studies will be made. In addition, information on the number of pregnancies, number of live births, menstrual history, and history of surgical or natural menopause will be obtained. Women with evidence of thyroid, adrenal or pituitary disease will be excluded. Comparisons of cases with controls will include tests for differences in known risk factors for CHD: hormones, blood pressure, lipoprotein lipids, glucose and insulin. Body mass index, weight, diet, exercise, alcohol, cigarette smoking, CHD history, blood pressure, and reproductive history will be examined as independent variables that might explain variation in CHD risk factors. The estimated effect of PCO on risk factors will be adjusted for significant independent variables. In summary, our study will provide information on whether women with PCO have a greater incidence of known risk factors for CHD than matched non-PCO women and will also provide information on the subsequent health status of these women. The results of this study will provide the feasibility for a multicenter study of the risks of heart and other diseases among women with PCO.