SLEEP APNEA & HYPERTENSION: ROLE OF S. NERVOUS SYSTEM

睡眠呼吸暂停和高血压性疾病的发病率很高。 高血压。这项研究将检验呼吸暂停发作的假设 夜间反复唤醒使血液升高，易患高血压 通过激活交感神经系统将压力提高到白天水平 释放压力荷尔蒙。 血浆和尿儿茶酚胺、肾素、神经肽Y、心房肌 将在治疗期间检查利钠因子、血压和皮质醇。 睡眠、休息、清醒，以及在轻微的行为压力之后。测试版 淋巴细胞上的肾上腺素能受体及其对肾上腺素能激动剂的反应 将被描述为。 这项研究将确定呼吸暂停高血压患者是否有过度的 对低氧应激或联合低氧加低氧的反应 屏住呼吸。轻度低氧会诱发，而低氧的影响 会检查去甲肾上腺素代谢，压力感受器功能， 对输注异丙肾上腺素敏感。 将对80名未服用药物的患者进行研究：20名有睡眠的高血压患者 20名无呼吸暂停的高血压患者，20名血压正常的睡眠呼吸暂停患者， 无呼吸暂停的血压正常者20例。所有患者都将入院接受2次治疗 在临床研究中心住一天。

There is a high co-morbidity between sleep apnea and essential hypertension. This study will test the hypothesis that apneic episodes predispose to hypertension by repeated nighttime arousals that raise blood pressure to daytime levels via activation of the sympathetic nervous system and release of stress hormones. Plasma and urinary catecholamines, renin, neuropeptide Y, atrial natriuretic factor, blood pressure, and cortisol will be examined during sleep, resting wakefulness, and after mild behavioral stressors. Beta adrenergic receptors on lymphocytes and the response to adrenergic agonists will be characterized. This study will determine if apneic hypertensives have an excessive response to the stress of hypoxia or to combined hypoxia plus breathholding. Mild hypoxia will be induced, and the effects of hypoxia will be examined on norepinephrine metabolism, baroreceptor functioning, and sensitivity to infused isoproterenol. Eighty unmedicated patients will be studied: 20 hypertensives with sleep apnea, 20 hypertensives without apnea, 20 normotensives with sleep apnea, and 20 normotensives without apnea. All patients will be admitted for a 2 day stay in the Clinical Research Center.