Burden of Obstructive Sleep Apnea in Stroke (BOSAST)

中风阻塞性睡眠呼吸暂停的负担 (BOSAST)

• 批准号: 7797482
• 负责人: JOEL E DIMSDALE
• 金额: $ 59.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797482
• 关键词: Address; Adhesions; Apnea; Area; Brain; Cell Adhesion; Cognition; Cognitive; Continuous Positive Airway Pressure; Data; Disease; Double-Blind Method; Fatigue; Fibrin fragment D; Fibrinogen; Hemostatic function; High Prevalence; Hypoxia; Impaired cognition; Inflammation; Inflammatory; Inpatients; Interleukin-6; Intervention; Left; Light; Literature; Location; Measures; Medical; Mental Depression; Observational Study; Obstructive Sleep Apnea; Oxygen; Patients; Randomized; Recovery; Rehabilitation Centers; Rehabilitation therapy; Reporting; Role; Severities; Side; Sleep; Sleep Fragmentations; Stroke; Survivors; Symptoms; Testing; Therapeutic; Time; cognitive function; depressive symptoms; design; improved; indexing; inflammatory marker; public health relevance; response; stroke rehabilitation; therapy design; treatment duration

DESCRIPTION (provided by applicant): Stroke survivors frequently complain of fatigue, depressive symptoms, and decreased cognitive functioning. These burdens complicate the recovery and rehabilitation from stroke. While there may be many contributing factors to these burdens, one factor in particular may be both terribly common and yet readily susceptible to intervention. Consistent reports from around the world demonstrate that >50% of stroke patients have obstructive sleep apnea (OSA), a disorder that is also associated with fatigue, depressive symptoms, and decreased cognitive functioning. OSA is also associated with increases in inflammatory products which themselves are associated with the same array of burdens. This study will examine 225 inpatients at a stroke rehabilitation center. Patients will be characterized in terms of fatigue, depressive symptoms, and problems with cognitive functioning as well as inflammation. Their sleep will be studied. Patients with OSA will be randomized to 10 days treatment double blind with either continuous positive airways pressure (CPAP) treatment or to sub-therapeutic CPAP treatment. After 10 days of treatment, the OSA patients as well as the stroke patient without OSA will be restudied in terms of their subjective burdens (fatigue, depressive symptoms, and cognitive functioning) and inflammation. The study will shed light on the impact of OSA on stroke patients' burdens of fatigue, depressive symptoms, and decreased cognitive functioning. It will clarify the possible role of inflammation on these burden symptoms, and it will test if treatment of OSA with CPAP has a specific effect to decrease burdens as well as inflammation. Keywords: obstructive sleep apnea, stroke, inflammation, cognition, depressive symptoms. PUBLIC HEALTH RELEVANCE: Strokes are commonly associated with burdens of fatigue, depressive symptoms, and cognitive problems. Obstructive sleep apnea has similar symptoms and is also very common in stroke patients. This study will determine if treating apnea in stroke patients will improve these burdens.

描述（由申请人提供）：中风幸存者经常抱怨疲劳，抑郁症状和认知功能降低。这些负担使中风的恢复和康复变得复杂。尽管这些负担可能有许多贡献因素，但尤其是一个因素既普遍又很普遍，却容易受到干预的影响。来自世界各地的一致报告表明，> 50％的中风患者患有阻塞性睡眠呼吸暂停（OSA），该疾病也与疲劳，抑郁症状和认知功能降低有关。 OSA还与炎症产品的增加有关，而炎症产品本身与相同的负担相关。这项研究将在中风康复中心检查225个住院患者。患者将以疲劳，抑郁症状以及认知功能以及炎症的问题来表征患者。他们的睡眠将被研究。 OSA患者将随机分配为10天治疗双盲，并进行连续的阳性气道压力（CPAP）治疗或亚治疗CPAP治疗。经过10天的治疗后，OSA患者以及没有OSA的中风患者将根据其主观负担（疲劳，抑郁症状和认知功能）和炎症。该研究将阐明OSA对中风患者疲劳，抑郁症状和认知功能降低的影响。它将阐明炎症对这些负担症状的可能作用，它将测试使用CPAP的OSA是否具有减轻负担和炎症的特定作用。关键词：阻塞性睡眠呼吸暂停，中风，炎症，认知，抑郁症状。公共卫生相关性：中风通常与疲劳，抑郁症状和认知问题负担有关。阻塞性睡眠呼吸暂停具有相似的症状，并且在中风患者中也很常见。这项研究将确定中风患者治疗呼吸暂停是否会增加这些负担。

项目成果

Continuous positive airway pressure for treatment of obstructive sleep apnea in stroke survivors: what do we really know?

• DOI: 10.1161/strokeaha.112.666248
• 发表时间: 2012-11
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Tomfohr LM;Hemmen T;Natarajan L;Ancoli-Israel S;Loredo JS;Heaton RK;Bardwell W;Mills PJ;Lee RR;Dimsdale JE
• 通讯作者: Dimsdale JE