PREDICTORS OF CARDIOVASCULAR DISEASE IN THE ELDERLY

有证据表明，心血管危险因素一直是 由研究确定的中年人群可能不会有同样的情况 对老年人的预测价值；特别是75岁和 上面。该提案寻求支持以评估与以下因素相关的因素 795名男性和女性队列中的心血管发病率和死亡率 在进行全面检查时年龄为75岁或以上 在1984至1987年间。这群人是兰乔·贝尔纳多的子集 慢性病研究，以及所有受试者的其他数据 来自12年前(1972-74年)的平均访问次数。所有必需的数据 已经收集了拟议的分析。(其他活动可能包括 从未来的年度发病率问卷中获得，以及年度死亡率 后续行动--这两项都得到了其他来源的支持)。死亡率 99%以上的受试者完成了随访，事件发病率 有关心肌梗死、冠脉搭桥手术的信息 还有中风。这一独特的数据库包括测量结果，它将允许： 1)推定的心血管风险影响的前瞻性分析 影响老年人疾病发病率的因素，2)前瞻性分析 危险因素变化对老年人事件的影响，3)探讨 与心血管事件无关的危险因素 年轻人口，但这在非常年长的人群中可能很重要，以及，4) 老年人群中假定危险因素的横断面描述。 该数据库已被汇编用于其他目的，其资金 没有规定对这些数据进行研究以评估相关的假设 为衰老干杯。需要3年的支持以进行分析和准备 利用这一独特资源的报告。

Evidence suggests that cardiovascular risk factors which have been identified by study of middle-aged populations may not have the same predictive value in the elderly; especially the "oldest old" aged 75 and above. This proposal seeks support to evaluate factors associated with cardiovascular morbidity and mortality in a cohort of 795 men and women aged 75 years or older at the time of a comprehensive examination conducted between 1984 and 1987. This cohort is a subset of the Rancho Bernardo Chronic Disease Study, and additional data is available for all subjects from a visit which averaged 12 years earlier (1972-74). All data necessary for the proposed analyses have been collected. (Additional events may be obtained from future annual morbidity questionnaires, and annual mortality follow-up -- both of which are supported by other sources). Mortality follow-up is complete for over 99% of subjects, and incident morbidity information is available for myocardial infarction, coronary bypass surgery and stroke. This unique database includes measurements which will allow: 1) prospective analyses of the effects of putative cardiovascular risk factors on disease incidence in the elderly, 2) prospective analyses of the impact of change in risk factors on events in the elderly, 3) exploration of risk factors not classically associated with cardiovascular events in younger populations but which may be important in the very old, and, 4) cross-sectional description of putative risk factors in an aged population. This database has been assembled for other purposes, the funding for which does not provide for study of these data to assess such hypotheses related to aging. Support is requested for 3 years to conduct analyses and prepare reports utilizing this unique resource.