BEHAVIORAL, ERP AND EEG ASYMMETRY IN AFFECTIVE DISORDERS

先前的研究表明，抑郁症患者的右脑功能会发生改变， 紊乱 我们的长期目标是帮助澄清 不同诊断亚型的右半球异常 情感性疾病，并评估抗抑郁药物的效果 关于这些异常。 我们建议延长和完成两个正在进行的 这些研究使用感知不对称的行为测量， 事件相关电位（ERP）测量半球不对称性。 具体而言，我们的目标是：（1）完成单极之间的比较 患者与双相患者（包括双相I与双相II）与 正常对照与非典型与典型的区别（见 第2项）;（2）在新样本中复制差异的初步发现 非典型抑郁症患者的偏侧知觉功能 具有诸如情绪反应性、嗜睡或食欲过盛等特征）， 典型抑郁症（没有这些特征的患者）;（3）测试患者 在抗抑郁药治疗前后， 行为或ERP测量的横向不对称性的改变持续存在， 治疗后消失;（4）评估治疗前是否有侧 不对称性可预测对标准的治疗反应， 三环类抗抑郁药（TCA）或单胺氧化酶抑制剂（MAOI）;（5） 将抑郁症患者知觉不对称的改变与更多 大脑半球不对称性的直接ERP测量;（6）使用 局部脑血流量（rCBF）。 我们建议增加研究1和研究2的样本量， 另外30名单相抑郁患者，30名双相抑郁患者 (15双极I型15例，双极II型15例）和30例正常对照。 研究1使用了 双耳分听和视速示成套测量 偏侧知觉功能 研究2同时测量ERP 半球不对称性的测量和知觉的行为测量 时间和空间辨别任务的不对称性。 试点研究将 测定10例抑郁症患者和20例正常对照者的rCBF， 静止条件和活化条件下。 测试患者 在至少10天的停药期后，并在6天后重新检测 用TCA、MAOI或安慰剂治疗7周。 临床 这项研究的意义在于需要更精确的诊断 艾滋病，促进抗抑郁药的选择，针对不同的 抑郁症的类型

Prior studies indicate that right brain function is altered in depressive disorders. Our long range goals have been to help clarify the nature of the right hemisphere abnormalities in different diagnostic subtypes of affective illness and to evaluate the effects of antidepressant medications on these abnormalities. We propose to extend and finish two ongoing studies that are using behavioral measures of perceptual asymmetry and event-related potential (ERP) measures of hemispheric asymmetry. Specifically, we aim: (1) to complete a comparison between unipolar patients vs. bipolar patients (including Bipolar I vs. Bipolar II) vs. normal controls in tandem with an atypical vs. typical distinction (see item 2); (2) to replicate in a new sample initial findings of differences in lateralized perceptual function between atypical depression (patients with features such as mood reactivity, hypersomnia or hyperphagia) and typical depression (patients without these features); (3) to test patients before and after treatment with antidepressants so as to determine whether alterations of lateral asymmetry on behavioral or ERP measures persist or disappear following treatment; (4) to evaluate whether pretreatment lateral asymmetries are predictive of therapeutic response to either a standard tricyclic antidepressant (TCA) or a monoamine oxidase inhibitor (MAOI); (5) to relate alterations of perceptual asymmetry in depressed patients to more direct ERP measures of hemispheric asymmetry; (6) to do a pilot study using measures of regional cerebral blood flow (rCBF). We propose to increase our sample sizes for Study 1 and Study 2 by testing an additional 30 unipolar depressed patients, 30 bipolar depressed patients (15 Bipolar I and 15 Bipolar II) and 30 normal controls. Study 1 uses a battery of dichotic listening and visual tachistoscopic measures of lateralized perceptual function. Study 2 simultaneously measures ERP measures of hemispheric asymmetry and behavioral measures of perceptual asymmetry in temporal and spatial discrimination tasks. A pilot study will measure the rCBF of 10 depressed patients and 20 normal controls in a resting condition and under activation conditions. Patients are tested after a minimum drug-free period of 10 days and are retested following 6 weeks of treatment with either a TCA, MAOI or placebo. The clinical significance of this research lies in the need for more precise diagnostic aids that facilitate the selection of antidepressants tailored to different types of depressive disorder.