课题基金 / 基金详情

ADOLESCENT DEPRESSION: NEUROPHARMACOLOGY AND BIOLOGY

ADOLESCENT DEPRESSION: NEUROPHARMACOLOGY AND BIOLOGY
青少年抑郁症：神经药理学和生物学
批准号：
3380835
负责人：
DENNIS P CANTWELL
金额：
$15.87万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
项目状态：
已结题
起止时间：
1987-02-01 至 1990-01-31
来源：
https://reporter.nih.gov/project-details/3380835
关键词：
3 methoxy 4 hydroxyphenylethyleneglycol adolescence (12-20) antidepressants catecholamines cortisol dopamine drug withdrawal epinephrine high performance liquid chromatography homovanillate human subject human therapy evaluation mental disorder chemotherapy neuropharmacology neurotransmitters norepinephrine normetanephrine nortriptyline placebos psychophysiology urinalysis

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中文摘要
翻译
这是一个请求四年来支持研究80名青少年的请求 严重抑郁症(MDD)住院患者。一项随机的任务， 去甲替林(NT)的双盲、安慰剂对照试验 在8周的时间内进行，然后是安慰剂停药阶段。 将对NT治疗的反应和复发的相关性进行研究。 需要研究的相关因素包括：精神病理学的家族聚集性， 神经内分泌测量、单胺测量及相关临床研究 (非抑郁的)症状。不同类型的疾病之间的相关性 生物措施，以及生物措施与临床和 家庭措施也将被调查。
英文摘要
This is a request for four years of support to study 80 adolescent inpatients with Major Depressive Disorder (MDD). A random assignment, double-blind, placebo-controlled trial of Nortriptyline (NT) will be carried out over an 8-week period followed by a placebo withdrawal phase. Correlates of response to and relapse from NT treatment will be studied. Correlates to be studied include: Familial aggregation of psychopathology, neuroendocrine measures, monoamine measures, and associated clinical (non-depressive) symptoms. Correlations between different types of biological measures, and between biological measures and clinical and family measures will also be investigated.
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ADOLESCENT DEPRESSION: NEUROPHARMACOLOGY AND BIOLOGY