NIMH-CRB PSYCHOBIOLOGY DEPRESSION PROGRAM-BIO

这项性中心合作研究的主要目的是测试 涉及神经生物学机制的假说 情感性精神障碍的病因学和维护。这个 开发了协作方法，以提供 具有不同学科专业知识的调查人员组成的联盟 来设计和进行研究。这项研究使用了制服 诊断标准和行为方法，以评估 多个生物系统在同一受试者中的功能。它 在基线无毒期内进行评估，并 在四周的抗抑郁药物治疗后。这 协作努力使更早和最新的测试成为可能 假设，并检查跨越和之间的相互作用 生物系统和行为。初始阶段的所有数据分析 假设检验阶段已基本完成。这 赠款申请代表对最后一期支持的请求 在此期间，假设检验的第二阶段 涉及两个或两个以上的生物系统和行为，将是 得出了一个结论。

The major aim this sex-center collaborative study was to test hypotheses which implicate neurobiological mechanisms in the etiology and maintenance of the affective disorders. The collaborative approach was developed in order to provide a consortium of investigators having expertise in diverse disciplines to design and conduct the research. The study utilized uniform diagnostic criteria and behavioral methods, so as to assess the functioning of multiple biological systems in the same subjects. It provided for assessment during a baseline drug-free period and after four weeks of anti-depressant drug treatment. This collaborative effort makes it possible to test earlier and current hypotheses, and to examine interactions across and among biological systems and behavior. All data analysis for the initial phase of hypothesis testing has been essentially completed. This grant application represents a request for a final period of support during which the second phase of the testing of hypotheses which involve two or more biological systems and behavior, will be brought to a conclusion.