GENETIC MARKERS IN AFFECTIVE DISORDERS

本研究的主要目的是检测主效基因， 情感障碍的传播。 这一目标将通过以下方式实现： 1. 确定疾病的谱系分离; 2. 采用分离分析技术，旨在解开 继承方式; 3。 用DNA进行连锁研究 限制性片段长度多态性（restriction fragment length polymorphism） 血统 如果建立联系，研究报告 还将致力于描述与基因相关的病例， 临床/生物学指标，试图定义同质性 疾病的子集。 长期目标将包括 作为风险预测因子的连锁标志物的评估， 以及作为风险预测因子的缺陷标志物的表征， 缺陷基因的鉴定和表征（或 基因），寻找基因的生物产物，并评估 基因-环境交互作用 新的DNA技术加上其他最近的方法学 取得的进展，如系统地获得家庭 数据、结构化访谈和精确的诊断标准，以及 一系列遗传模式的可用性， 为了解开基因机制， 情感性疾病 这反过来又会对以下方面产生重大影响： 病因学、疾病分类学、病理生理学以及可能的预防 和情感障碍的治疗。

The main objective of this study is to detect major genes in the transmission of affective disorders. This goal will be attained by 1. ascertaining pedigrees segregating for the illness; 2. employing segregation analysis techniques aimed at unraveling the mode of inheritance; and 3. conducting linkage studies with DNA markers (restriction fragment length polymorphisms) in suitable pedigrees. Should linkage (or linkages) be established, the study will also aim to characterize the genetically linked cases on clinical/biological measures in an attempt to define homogeneous subsets of the disorder. Longer range goals will include the assessment of linked markers as risk predictors, the identification and characterization of the defective markers as risk predictors, the identification and characterization of the defective gene (or genes), searching for the gene's biological products, and assessing gene-environment interaction. The new DNA technology coupled with other recent methodologic advances, such as approaches to systematically obtaining family data, structured interviews and precise diagnostic criteria, and the availability of a range of genetic modes, holds much promise for unraveling the genetic mechanisms that underlie subtypes of affective illness. This, in turn, would have major implications for the etiology, nosology, pathophysiology, and, possibly, prevention and treatment of affective disorders.