MESOCORTICAL ANATOMY AND PLASTICITY

此申请概述了设计的持续(7-9年)研究计划 阐明皮质(中皮质)的神经解剖学组织 形成了东半球猴子所谓的边缘叶。这个 中皮质构成大脑皮质的一大部分，位于大脑的内侧表面 大脑半球，以及众所周知的区域，如扣带回， 海马旁回、后眶额区和颞极区 是主要的元素。主要的长期目标是了解他们的 与大脑皮层的关系。概述了三个持续的目标：(1) 第一个，也是主要目标是进行实验性神经解剖学研究 中脑皮质的顺行和逆行联系 示踪技术，(2)第二个目标以光学显微镜为中心 像杏仁核这样的颞叶深层结构的神经再支配研究， (3)以评估轴突为代表的第三个目标。 荧光法在皮质间连接中的侧支作用 双重标记技术。联系研究解决了内在的和 中脑皮层的连合投射，神经再支配的研究集中在 杏仁外侧核和双标记法研究轴突 海马区后旁、扣带回和下丘脑的侧支分布 轨道-额叶区域。本研究既有基础，也有临床。 神经科学的关联性。中皮质是连接的，并且 在结构上居于中间的，共享 将联合皮质与边缘系统相互连接。当这件事 神经系统疾病衰弱障碍中的关系被破坏 与记忆、注意力和情绪的结果有关。神经再支配 研究重点集中在头部创伤和脑部损伤常见的颞叶区域 与创伤后常见的行为变化有关 临床环境。为节省成本，个别调查如下 以连锁的方式设计，并部分借鉴了 哈佛大学过去15年收集的非人类灵长类动物材料 医学院(1969-1978)和爱荷华大学(1979-1984)。没有一个 拟议的调查完全依赖于所有新的 研究材料。

This application outlines a continuing (years 7-9) research plan designed to elucidate the neuroanatomical organization of the corices (mesocortices) that form the so-called limbic lobe in the old-world monkey. The mesocortices form a large part of the cortex on the medial surface of the cerebral hemisphere, and well-know areas like the cingulate gyrus, parahippocampal gyrus, posterior orbitofrontal area and temporal polar area are major elements. The major long term goal is to understand their relationship with the neocortex. Three continuing aims are outlined: (1) the first, and major aim entails experimental neuroanatomical studies on the connections of the mesocortices using anterograde and retrograde tracing techniques, (2) the second aim centers around light microscopic reinnervation studies in deep temporal lobe structures like the amygdala, (3) the third aim is represented by studied that assess axon collateralization in mesocortica connections using fluorexcent double-labeling techniques. Connection studies address the intrinsic and commissural projection of the mesocortices, reinnervation studies focus on the lateral amygdaloid nucleus and double-labeling studies assess axon collateralization in the posterior parahippocampal, cingulate and orbito-frontal areas. The research has basic as well as clinical neuroscience relevance. The mesocortices are connectionally and architecturally intermediate in structure, sharing the features of interconnecting the association cortices with the limbic system. When this relationship is disrupted in neurological disease debilitating disorders relating to memory, attention and emotion results. The reinnervation studies focus on temporal lobe areas involved frequently in head trauma and hold relevance to post-traumatic changes in behavior seen frequently in the clinical setting. To conserve costs the individual investigations are designed in an interlocking fashion and draw in part on a collection of non-human primate material gathered over the past 15 years at Harvard Medical School (1969-1978) and the University of Iowa (1979-1984). None of the proposed investigations rely exclusively on the generation of all new research material.