Epitranscriptomic regulation of learning and memory

本项目旨在研究哺乳动物大脑中真核信使RNA中最常见的内部修饰m6A。成人大脑中含有高水平的可逆m6A，表明m6A在突触可塑性（学习和记忆的细胞基础）过程中调节神经元转录组。该项目将使用表观转录组学来研究RNA上的100多种修饰，其中许多尚未被表征。通过分子和小鼠行为分析，预期的结果是深入了解学习和记忆的转录后调控，这对于在不断变化的环境中生存至关重要。

This project aims to investigate m6A, the most prevalent internal modification in eukaryotic messenger RNA, in the mammalian brain. The adult brain contains a high level of reversible m6A, suggesting that m6A regulates the neuronal transcriptome during synaptic plasticity, the cellular basis of learning and memory. This project will use epitranscriptomics to investigate the more than 100 modifications on RNA, many of which are not yet characterised. Through molecular and mouse behavioural assays, the expected outcomes are insights into the post-transcriptional regulation underlying learning and memory, essential for survival in a constantly changing environment.