MENSTRUALLY RELATED CHANGES IN COGNITIVE FUNCTION

拟议的项目是长期跨学科努力的一部分 月经相关性月经过多的本质和机制的阐明 改变。目前的焦点是经前改变的程度。 一些女性的认知和精神运动功能。事实证明， 虽然大多数女性没有明显的周期性认知变化，但也有一些 女性，特别是那些有经前焦虑症的女性-一致地报告 这样的变化。我们的初步数据表明，这些变化可能是 客观地证实了。它们可能正在进行复杂的协调测试 可能与性腺激素水平的变化有关。 该项目的目标是：1)客观确认(或不确认) 主诉高血压患者经前认知功能改变的研究 2)对性腺和脑垂体影响的调查 荷尔蒙对聚焦功能的影响。3)澄清 经前认知改变与经前焦虑症的关系； 4)阐明经前认知可能存在的选择多样性 精神运动功能； 120名寻求治疗经前焦虑症的妇女(60人报告 认知变化和60名未报告此类变化的女性)和30名患有 卵泡中期和黄体晚期不检测PMC。这个 一组8个测试的设计涵盖了广泛的认知能力 精神运动功能具有广泛的复杂性。荷尔蒙 每天早上都会对血浆水平以及情绪和行为进行评估 在测试之前。烦躁不安的PMC的女性将被发现足够严重 保证治疗将进入治疗方案的目的之一 通过创造不同的方式来消除排卵和激素波动 荷尔蒙环境(丹参、乙炔雌二醇和三氢叶酸)。 在这些情况下，精神运动和认知功能的变化将 与前处理基线进行比较。 拟议的项目应有助于更好地了解其影响 垂体和性腺激素对认知和精神运动的影响 性能。它还将有助于解决源于性别歧视的问题 从基于少数人的印象而对整个人口进行刻板印象 个人。

The proposed project is part of a long term interdisciplinary effort of elucidation of the nature and underlying mechanisms of menstrually related changes. The present focus is the degree of premenstrual change in cognitive and psychomotor functions in some women. It has been shown that while most women do not have significant cyclic cognitive changes, some women, especially those with premenstrual dysphoria - consistently report such changes. Our preliminary data point that these changes may be objectively confirmed. They are probably in complex coordinated tests and might be associated with changes in levels of gonadal hormones. The project is aimed at: 1) Objective confirmation (or disconfirmation) of premenstrual changes of cognitive functions in women who complain of such changes; 2) Investigation of the influence of gonadal and pituitary hormones on the functions in focus. 3) Clarification of the association of premenstrual cognitive changes with premenstrual dysphoria; 4) elucidation of a possible selection diversity of premenstrual cognition and psychomotor functions; 120 Women who seek treatment for premenstrual dysphoria, (60 who report cognitive changes and 60 who do not report such changes) and 30 women with no PMC will be tested at mid-follicular phase and late luteal phase. The battery of 8 tests has been designed to cover a wide range of cognitive and psychomotor functions with a wide range of complexity. Hormonal plasma levels as well as mood and behavior will be assessed every morning prior to the tests. Women whose dysphoric PMC will be found severe enough to warrant treatment will enter into one of the treatment protocols aimed at elimination of ovulation and hormonal fluctuation by creating different hormonal environments (Danocrine, ethinyl estradiol and triphasil). Changes in psychomotor and cognitive functions under these conditions will be compared to pretreatment baselines. The proposed project should lead to better understanding of the influence of pituitary and gonadal hormones on cognitive and psychomotor performance. It will also contribute to settle the sex bias originating from stereotyping entire population based on impressions derived from few individuals.