RESEARCH CENTER ON THE PSYCHOBIOLOGY OF ETHNICITY

尽管人们越来越多地意识到心理生物学和 精神药理学对少数民族精神卫生患者的护理， 以及对大量种族和文化多样性的日益认识 在心理生物过程和反应中，相对较少的受控 已经进行了调查以审查这些问题。结果： 这样的研究不仅对慢性阻塞性肺疾病患者的临床护理具有重要意义 不同的种族背景，但也有重大的基础科学 这意味着什么。为了继续解决这些重要的临床和 理论问题的系统性，这项申请寻求 继续支持儿童心理生物学研究中心 种族问题。 在坚实的基础设施、研究模型、 和已经建立的协作网络，该中心将 继续促进和促进对与 种族和心理生物学之间的接口。创新研究 设计和最先进的方法，包括那些源自 药物遗传学、分子生物学、脑成像和时间生物学将 被用来进一步描述种族差异背后的机制 (和相似之处)精神药物反应，以检查心理生物学 “文化特异症”及其病因学地位 与现有DSM-III-R和DSM-IV诊断的关系，并探讨 其他心理生物学和精神药理学问题 种族和文化。 在这个供资周期内，中心发起的六个项目将是 实施。这些包括：(1)中国民族差异的形成机制 精神药物反应；(2)种族、脑成像和抗抑郁药 反应；(3)患者的精神诊断和生物标志物 有神经衰弱、慢性疲劳综合征和抑郁症；(4)种族 迟发性运动障碍；(5)智力低下的全血5-羟色胺： 种族影响；以及，(6)咖啡因对脑灌流的影响 非裔美国人和高加索人。此外，还有一些探索性的 项目将在整个赠款期限内开发。 中心的活动，其主要重点是心理生物学 问题，将补充关于少数民族群体的其他研究，这些研究 主要是心理社会性质的，并有助于确保我们的努力 在了解迅速增长的少数民族面临的问题时 人口是全面的，涵盖了整个 生物心理社会模式。

Despite an increased awareness of the relevance of psychobiology and psychopharmacology to the care of ethnic minority mental health patients, and the growing recognition of substantial ethnic and cultural diversity in psychobiological processes and responses, relatively few controlled investigations have been conducted to examine these issues. Results of such studies are important not only for the clinical care of patients with divergent ethnic backgrounds, but also have significant basic science implications. In order to continue addressing these important clinical and theoretical issues in a systematic manner, this application seeks continued support for the Research Center on the Psychobiology of Ethnicity. Building on the solid foundation of the infrastructure, research models, and collaborative networks that have been established, the Center will continue to foster and promote research on issues relevant to the interface between ethnicity and psychobiology. Innovative research designs and state-of-the-art methodologies including those derived from pharmacogenetics, molecular biology, brain imaging and chronobiology will be utilized to further delineate mechanisms underlying ethnic differences (and similarities) in psychotropic response, to examine the psychobiologic and nosologic status of "culturally specific syndromes" and their relationship to existing DSM-III-R and DSM-IV diagnoses, and to explore other psychobiologic and psychopharmacologic issues in the context of ethnicity and culture. During this funding cycle, six Center-initiated projects will be implemented. These include: (1) Mechanisms of Ethnic Difference in Psychotropic Responses; (2) Ethnicity, Brain Imaging and Antidepressant Response; (3) Psychiatric Diagnosis and Biological Markers in Patients with Neurasthenia, Chronic Fatigue Syndrome and Depression; (4) Ethnicity and Tardive Dyskinesia; (5) Whole Blood Serotonin in Mental Retardation: Ethnic Influences; and, (6) The Effect of Caffeine on Cerebral Perfusion in African-Americans and Caucasians. In addition, a number of explorative projects will be developed throughout the duration of the grant. The activities of the Center, with its primary focus on psychobiologic issues, will complement other research on ethnic minority groups that are predominately psychosocial in nature, and help to ensure that our efforts in understanding issues confronting the rapidly increasing ethnic minority populations are comprehensive and encompass the entirety of the biopsychosocial model.