SPINAL CORD CONTROL OF MOTOR ACTIVITY

脊髓在所有神经元连接后表现出运动功能 脊椎上结构被切断。我们的工作对脊髓运动做出了贡献 神经生理学通过检查负责的神经机制 脊椎龟三种抓挠反射的产生。这个 每种类型的运动神经元活动模式的序列 被神经肌肉固定的脊椎龟会产生划痕 封锁。这种制剂具有机械稳定性，以允许 脊髓神经元胞内记录在产生 抓挠反射运动活动。 我们将表征兴奋性和抑制性突触电位。 运动神经元在三种形式的抓挠反射中的应用 细胞内记录技术。我们将使用这些数据来预测 脊髓中间神经元产生划痕的时序特征 条件反射。我们将研究脊髓中间神经元的活动模式。 在这些反射过程中直接使用细胞内和细胞外 录音技术。我们将检查限制性制剂，包括 有两到四段脊髓，能够产生 刮擦马达图案。我们将使用这些数据来确定分段 产生各种划痕形式的中间神经元的位置 条件反射。我们将利用这些受限制的药物开发体外制剂 适合于药物治疗的脊髓部分 发电机网络。我们将使用我们的PDP-11/23+计算机来分析 在划痕过程中的运动模式，并将开发图形技术 划痕电机图案的计算机模式识别。我们会研究 混合了几种形式的刮痕反射，由 同时刺激身体表面的两个部位，以便 确定运动程序的选择和中断规则。 我们将使用我们的数据来测试一组关于 脊髓运动模式发生器的神经元间组织。自.以来 人类的脊髓与低等脊椎动物的脊髓相似，我们的 这项工作将成为那些目前正在开发的人有用的工作假设 脊椎损伤人类的神经运动假体。

The spinal cord exhibits motor function after all neuronal connections with supraspinal structures are severed. Our work contributes to spinal motor neurophysiology by examining the neuronal mechanisms responsible for the production of three types of scratch reflexes in the spinal turtle. The sequences of motor neuron activity patterns characteristic of each type of scratch are produced in a spinal turtle immobilized with neuromuscular blockade. This preparation has the mechanical stability to allow intracellular recordings from spinal cord neurons during the production of scratch reflex motor activity. We will characterize the excitatory and inhibitory synaptic potentials in motor neurons during the three forms of the scratch reflex using intracellular recording techniques. We will use these data to predict the timing characteristics of spinal interneurons generating the scratch reflex. We will examine the activity patterns of spinal interneurons directly during these reflexes using both intracellular and extracellular recording techniques. We will examine restricted preparations consisting of two to four segments of the spinal cord that are capable of producing scratch motor patterns. We will use these data to determine the segmental locations of the interneurons generating each of the forms of the scratch reflex. We will develop in vitro preparations using these restricted portions of the spinal cord suitable for pharmacological manipulations of the generator network. We will use our PDP-11/23+ computer to analyze the motor patterns during the scratch and will develop graphical techniques for computer pattern recognition of the scratch motor patterns. We will study blends of several forms of the scratch reflex that are produced by simultaneous stimulation of two sites on the body surface in order to determine the rules of selection and interruption of motor programs. We will use our data to test a set of working hypotheses concerning the interneuronal organization of spinal cord motor pattern generators. Since the spinal cord of humans is similar to that of the lower vertebrates, our work will serve as useful working hypotheses for those currently developing neural motor prostheses for spinal-injured humans.