NEURONAL ACTIVITY WITH HUMAN HIGHER FUNCTIONS

伴随人类高级功能的皮层电图（ECoG）变化 直接记录在大脑皮层， 患者在手术过程中遇到的独特机会 癫痫的治疗 寻求ECoG的变化， 特异于那些被独立鉴定为 通过电刺激映射来运作，在那里， 具体的，也就是说，在使用相同的感官输入的任务中不存在， 处理不同的高级功能。 这一建议是一种延伸 我们以前的工作，其中变化是视觉上确定的平均 皮层脑电图对无声命名具有解剖和行为特异性： 慢 额叶语言部位的诱发电位（EP）和 后语言位点 这种去水化是用 频谱密度技术在个体安静试验中的ECoG 命名和特异性经统计学证实。 一张EP，独一无二 形态与解剖和行为特异性，以短期言语 记忆已经被识别，测量，并证实了特异性 统计学上。 沉默词时皮层脑电图变化的初步观察 阅读与更改相比有一些差异， 无声命名 本文通过以下方式扩展了这些研究： 与运动言语功能相关的EP，确定EP是否与 记忆也发生在额叶部位，证实ECoG的变化与解剖 和行为特异性，以阅读，并确定ECoG事件与 这种对听觉命名、单词重复和语音的特异性 识别. 这些事件发生的群体变异性 将确定事件（迄今为止在个体患者中确定的）。 这些ECoG事件的程度和行为相关性的细节 将测试语言皮层是由马赛克组成的假设， 相当明显的行为特异性 事件发生的时间在不同的 同一患者的研究中心将确定连续或平行的程度 处理特定功能。 这些事件的形态可能 表明了潜在的神经生物学机制。 这些研究将增加 我们对人类大脑语言功能发生位置的理解， 在这些行为中起作用的神经生物学机制。

Electrocorticographic (ECoG) changes accompanying human higher functions involving language are recorded directly from cortex in awake, behaving patients during the unique opportunity that occurs with the surgical treatment of epilepsy. ECoG changes are sought that are anatomically specific to those cortical sites independently identified as essential to that function by electrical stimulation mapping, and there, behaviorally specific, that is, absent on tasks using the same sensory input but processed with different higher functions. This proposal is an extension of our previous work where changes were visually identified in the averaged ECoG that had anatomic and behavioral specificity to silent naming: slow evoked potentials (EP's) at frontal language sites and desynchronization at posterior language sites. That desynchronization has been measured with spectral density techniques on ECoG during individual trials of silent naming, and the specificity confirmed statistically. An EP of unique morphology with anatomic and behavioral specificity to short-term verbal memory has been identified, measured, and that specificity confirmed statistically. Preliminary observations of ECoG changes during silent word reading have been made with some differences compared to changes with silent naming. The present posposal extends these studies by: Measurement of EP's related to motor speech function, determining if the EP related to memory also occurs at frontal sites, confirming ECoG changes with anatomic and behavioral specificity to reading, and identifying ECoG events with such specificity to auditory naming, word repetition and speech sound identification. The population variability in the occurrence of these events (identified to date in individuals patients) will be determined. The details of the extent and behavioral correlation of these ECoG events will test the hypothesis that language cortex is organized in mosaics of considerable behavioral specificity. The timing of events at different sites in the same patient will determine the degree of serial or parallel processing of a particular function. The morphology of these events may suggest underlying neurobiologic mechanisms. These studies will increase our understanding of where in the human brain language functions occur, and the neurobiologic mechanisms operative there during those behaviors.