EXCITATORY AMINO ACIDS IN THE NUCLEUS ACCUMBENS

兴奋性氨基酸被认为是神经递质和 伏隔核中的神经调节剂。当不同的兴奋性氨基酸 胃酸激动剂被微量注射到伏隔核中，它们会产生一种 有明显的运动亢进反应。这些研究的总体目标是 为了了解这些激动剂如何与不同的神经系统相互作用 以便在伏隔核内产生协调运动 回应。其具体目的是确定1)多巴胺能 伏核中的神经元参与兴奋性氨基酸 诱发的运动亢进反应。因此，将进行实验，以 确定多巴胺能神经元是否对反应和 这些神经元是否直接与兴奋性氨基酸相互作用，2 兴奋性氨基酸是否与5-羟色胺能胆碱能相互作用， 伏隔核内的GABA能和谷氨酸能神经元 这种相互作用在高动力反应中的可能作用，3)是否 兴奋性氨基酸的作用是通过相互作用来调节的。 有兴奋性氨基酸受体，4)运动亢进 作用于伏隔核的不同药物产生的反应是 由相同的神经机制介导，5)是否存在运动亢进 对发现的物质给予伏隔内酯产生的反应 内源性的，如叶酸衍生物，促甲状腺激素释放激素 和喹啉酸是通过激活兴奋性氨基来调节的。 酸性受体，6)兴奋性氨基酸是否激活 受体参与过度运动反应的调节 由激活中脑边缘多巴胺能神经元的条件产生。 据推测，兴奋性氨基酸起神经递质的作用。 或者伏隔核中的神经调节剂。然而，身份的身份 兴奋性氨基酸及其在该部位的功能作用不是 为人所知。对这项提案的研究应该能让我们深入了解 兴奋性氨基酸在伏隔核中的功能作用。

Excitatory amino acids have been postulated to act as neurotransmitters and neuromodulators in the nucleus accumbens. When different excitatory amino acids agonists are microinjected into the nucleus accumbens, they produce a marked hypermotility response. The overall objective of these studies is to understand how these agonists interact with different neuronal systems in the nucleus accumbens in order to produce a coordinated locomotor response. The specific aims are to determine 1) what role dopaminergic neurons in the nucleus accumbens play in the excitatory amino acid induced-hypermotility response. Thus, experiments will be performed to determine whether dopaminergic neurons are essential for the response and whether these neurons interact directly with excitatory amino acids, 2) whether excitatory amino acids interact with serotonergic cholinergic, GABAergic, and glutamatergic neurons in the nucleus accumbens and the possible role of this interaction in the hypermotility response, 3) whether the effects of excitatory amino acids are mediated through an interaction with excitatory amino acid receptors, 4) whether the hypermotility responses produced by different drugs that act in the nucleus accumbens are mediated by the same neuronal mechanisms, 5) whether the hypermotility responses produced by the intraccumbens administration of substances found endogenously such as folic acid derivatives, thyrotropin-releasing hormone and quinolinic acid are mediated through the activation of excitatory amino acid receptors, 6) whether the activation of excitatory amino acid receptors is involved in the mediation of the hypermotility response produced by conditions which activate the meso-limbic dopaminergic neurons. It has been postulated that excitatory amino acids act as neurotransmitters or neuromodulators in the nucleus accumbens. However, the identity of the excitatory amino acids and their functional actions at this site are not known. The studies of this proposal should provide insight into the functional role of excitatory amino acids in the nucleus accumbens.