How the immune system recognises vitamin B-based allergies

该项目旨在评估能够刺激哺乳动物和两栖动物中维生素B反应性T细胞的分子的范围，以及这些分子在不同微生物中的保守或变异程度。T细胞是识别外来分子的免疫细胞，包括多肽、脂类和维生素B代谢物，与特定的抗原呈递分子结合。在哺乳动物中，粘膜相关不变T细胞识别以维生素B为基础的分子，目前仍知之甚少。这个项目将免疫学与结构生物学和化学相结合，旨在了解免疫系统如何检测不同微生物产生的分子。

This project aims to evaluate the range of molecules that can stimulate vitamin B-reactive T cells in mammals and amphibians, and the degree of conservation or variation in these molecules among diverse microorganisms. T cells are immune cells that recognise foreign molecules, including peptides, lipids and vitamin B metabolites, bound to specialised antigen-presenting molecules. In mammals, Mucosal Associated Invariant T cells, still poorly understood, recognise Vitamin B-based molecules. Combining immunology with structural biology and chemistry, this project aims to understand how the immune system detects molecules produced by diverse microorganisms.