Understanding the life and death of Mucosal-associated invariant T cells

了解粘膜相关不变 T 细胞的生与死

• 批准号: DP210101416
• 负责人: A/Prof Alexandra Corbett
• 金额: $ 30.55万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101416
• 关键词: Understanding; life; death; Mucosal; associated

Cell death of naïve T cells in lymphoid organs is well-understood. However, T cells only gain their function upon activation, and how activated T cells regulate their life or death remains unclear. Mucosal-associated Invariant T (MAIT) cells are abundant in non-lymphoid tissues as key local players in immunity, and share some features of activated conventional T cells. This project aims to define how MAIT cell survival and death are controlled. It combines methods we developed to track MAIT cells in vivo with expertise in cell death analysis. This project is expected to elucidate the complex mechanisms controlling MAIT cell survival/death and increase our fundamental understanding of cell death mechanisms of activated T cells.

淋巴器官中幼稚 T 细胞的细胞死亡是众所周知的。然而，T细胞只有在激活后才能发挥其功能，而激活的T细胞如何调节其生命或死亡仍不清楚。粘膜相关不变 T (MAIT) 细胞在非淋巴组织中大量存在，是局部免疫的关键参与者，并且具有活化的常规 T 细胞的一些特征。该项目旨在定义如何控制 MAIT 细胞的存活和死亡。它将我们开发的体内追踪 MAIT 细胞的方法与细胞死亡分析方面的专业知识相结合。该项目有望阐明控制 MAIT 细胞存活/死亡的复杂机制，并增加我们对活化 T 细胞的细胞死亡机制的基本理解。