EXCITATORY AMINO ACIDS IN THE NUCLEUS ACCUMBENS

兴奋性氨基酸被认为是神经递质， 神经调节剂的作用 当不同的兴奋性氨基酸 酸激动剂被显微注射到丘脑核中，它们产生一种 明显的运动性亢进反应。 这些研究的总体目标是 为了了解这些激动剂如何与不同的神经系统相互作用， 以产生协调的运动 反应 具体的目的是确定1）多巴胺能神经元 延髓核中的神经元在兴奋性氨基酸中起作用， 诱导性运动过度反应。 因此，将进行实验以 确定多巴胺能神经元是否是反应所必需的， 这些神经元是否直接与兴奋性氨基酸相互作用，2） 兴奋性氨基酸是否与胆碱能胆碱能相互作用， 丘脑底核和小脑顶核的GABA能和GABA能神经元 这种相互作用在运动过度反应中的可能作用，3）是否 兴奋性氨基酸的作用是通过相互作用介导的 兴奋性氨基酸受体，4）是否运动过度 不同药物在丘脑核中产生的反应是 由相同的神经元机制介导，5）是否运动过度 由被发现的物质的intrabens管理产生的反应 内源性如叶酸衍生物、促甲状腺激素释放激素 和喹啉酸是通过激活兴奋性氨基 酸受体，6）是否激活兴奋性氨基酸 受体参与高运动性反应的介导 由激活中脑边缘多巴胺能神经元的条件产生。 据推测，兴奋性氨基酸作为神经递质 或神经调质。 然而， 兴奋性氨基酸及其在该位点的功能作用不是 知道的 对这一建议的研究应有助于深入了解 兴奋性氨基酸在丘脑核中的功能作用。

Excitatory amino acids have been postulated to act as neurotransmitters and neuromodulators in the nucleus accumbens. When different excitatory amino acids agonists are microinjected into the nucleus accumbens, they produce a marked hypermotility response. The overall objective of these studies is to understand how these agonists interact with different neuronal systems in the nucleus accumbens in order to produce a coordinated locomotor response. The specific aims are to determine 1) what role dopaminergic neurons in the nucleus accumbens play in the excitatory amino acid induced-hypermotility response. Thus, experiments will be performed to determine whether dopaminergic neurons are essential for the response and whether these neurons interact directly with excitatory amino acids, 2) whether excitatory amino acids interact with serotonergic cholinergic, GABAergic, and glutamatergic neurons in the nucleus accumbens and the possible role of this interaction in the hypermotility response, 3) whether the effects of excitatory amino acids are mediated through an interaction with excitatory amino acid receptors, 4) whether the hypermotility responses produced by different drugs that act in the nucleus accumbens are mediated by the same neuronal mechanisms, 5) whether the hypermotility responses produced by the intraccumbens administration of substances found endogenously such as folic acid derivatives, thyrotropin-releasing hormone and quinolinic acid are mediated through the activation of excitatory amino acid receptors, 6) whether the activation of excitatory amino acid receptors is involved in the mediation of the hypermotility response produced by conditions which activate the meso-limbic dopaminergic neurons. It has been postulated that excitatory amino acids act as neurotransmitters or neuromodulators in the nucleus accumbens. However, the identity of the excitatory amino acids and their functional actions at this site are not known. The studies of this proposal should provide insight into the functional role of excitatory amino acids in the nucleus accumbens.