Intelligent Decision Support and Control Technologies for Continuous Manufacturing of Pharmaceuticals and Fine Chemicals

尽管连续结晶为创新制造提供了显著的好处，但对颗粒产品的定量属性(形状、形状、大小)进行实时、可靠的监控仍然是一个巨大的挑战。虽然颗粒属性对产品的下游加工至关重要，但目前没有一种解决方案允许处理来自在线传感器的数据，以便在多个制造步骤中可靠地实时提取这些属性，并随后将这些知识用于入侵检测和工艺控制。为该部门开发解决方案需要终端用户需求驱动的多项技术方面的专业知识。产业共同创建者将提供要求，申请者范围内的专业知识，以确保实现方案的目标。这笔赠款将使建立一个工艺试验台成为可能，随着项目的成熟，该试验台将提供给一系列国家和国际用户和应用界。这项活动将支持创建需求和技术路线图，从而向研究和商业团体通报未来的机会。该项目还将为社区带来以下附加值：-项目和参与团队的跨学科性质将激发新的解决方案，并通过分享从不同角度执行研究的最佳实践来促进创造力-PDRA将把他们的专门知识应用于联合开发任务，使他们能够在一系列领域获得全面的知识和专业知识，并通过这样做提供训练有素、才华横溢的工程师，从而推动这些创新解决方案的部署-该项目致力于整合多个不同的架构层，将物理基础设施转变为一个灵活的平台，支持一系列应用程序，同时用户可以访问

Although continuous crystallisation provides significant benefits to innovative manufacture, the key challenge of real time, robust monitoring of quantitative attributes (form, shape, size) of particulate products still remains a massive challenge. While particle attributes are crucial for downstream processing of products, no current solution allows the processing of data from in-line sensors to reliably extract these attributes in real time across multiple manufacturing steps and the subsequent use of this knowledge for IDS and control of processes. The development of solutions for the sector requires expertise across many technologies driven by end user requirements. Industrial co-creators will provide the requirements, the range of expertise within the applicants ensuring that the goals of the programme are met. The grant will enable the establishment of a process test-bed which as the project matures, will be made available to a range of national and international user and application communities. This activity will support the creation of a requirement and technology roadmap, in so doing informing both the research and commercial communities on future opportunities. The project will also yield the following added value to the community: - the cross-disciplinary nature of the project and participating teams will stimulate new solutions and promote creativity through sharing best practice in executing research from different perspectives- the PDRAs will be applying their know-how to joint development tasks, allowing them to gain comprehensive knowledge and expertise across a range of field and in so doing provide trained, talented engineers that will fuel the deployment of these innovative solutions- the project addresses the integration of a number of distinct architectural layers to transform a physical infrastructure into a flexible platform which supports a range of applications whilst accessible to users