EFFECT OF CERAMIC GRAFTS ON TOOTH ERUPTION

残存的上颌牙槽裂常见于 腭裂患者。植骨矫正骨缺损 被安排在恒牙列萌出的时间。这块骨头 移植物稳定了牙骨段，改善了牙槽骨连续性， 并允许裂隙中未萌出的牙齿通过骨组织萌出。 如果有一项措施，病人的发病率和医疗费用将大大降低 合成材料被用来代替自生颗粒 从髂骨移植松质骨(APCB)。 近年来，磷酸钙陶瓷(CPC)被广泛应用于 替代骨移植在口腔颌面外科中的应用。两大 CPC、不可吸收羟基磷灰石(HA)和可吸收β 磷酸三钙(Tcp)已有效地增强了 牙槽突脊与牙槽骨不连续的修复 缺陷。磷酸钙骨水泥的生物吸收能力的变异性被认为是 次于溶液介导的降解过程。到目前为止，这 仍然是一个有争议和有争议的问题。 这项建议具体目的是将各种CPC放在一个区域 动态骨重塑，即长出恒牙。我们希望 确定磷酸钙骨水泥、透明质酸等植入物对活性恒牙的影响 牙萌出，以及它们的生物吸收能力。这将是 使用3-4个月大的小猫完成的，这些小猫已经有了他们的乳汁 拔除下颌第二、第三前磨牙。拔牙插座 将与TCP、HA或APCB一起包装。恒牙萌出 将通过植入材料与APCB进行比较，进行假手术 小猫已经拔掉了牙齿，但没有植入植入物，也没有得到治疗， 对照小猫有正常的牙萌出模式。小猫们将会成为 每隔一个月牺牲一次，并对其进行放射分析 组织学上。将对冰冻的下颌骨进行组织切片。 一台冷冻切片机。使用两只猫进行的初步研究表明， 使用上述模型的HA种植延缓了牙齿发育和 喷发。 这项研究获得的数据将有助于唇裂患者的治疗 并建立了一种动物模型来研究CPC和CpG之间的相互作用。 长牙了。

Residual maxillary alveolar cleft defects are frequently encountered in cleft palate patients. Correction of the osseous defect with a bone graft is timed to coincide with eruption of the permanent dentition. The bone graft stabilizes the dentoosseous segments, improves alveolar continuity, and allows unerupted teeth in the cleft to erupt through osseous tissue. Patient morbidity and medical expense would be substantially decreased if a synthetic material was used to substitute for the autogenous particulate cancellous bone (APCB) graft from the ilium. Recently calcium phosphate ceramics (CPC) have been widely used as substitute bone grafts in oral and maxillofacial surgery. The two major CPC, the non-resorbable hydroxyapatites (HA) and the resorbable beta tricalcium phosphates (TCP) have been effective in augmentating dento-alveolar ridges and in repair of alveolar bone discontinuity defects. The variability of bioresorbability of the CPC has been though to be secondary to solution-mediated processes of degradation. To date, this still remains a controversial and debated issue. The specific aim of this proposal is to place various CPC in an area of dynamic bone remodeling i.e. over an erupting permanent tooth. We hope to ascertain the effects of the CPC implants i.e. TCP, HA, on active permanent tooth eruption, as well as their bioresorbability. This will be accomplished using 3-4 month old kittens that have had their deciduous mandibular second and third premolars extracted. The extraction sockets will be packed with either, TCP, HA or APCB. Permanent tooth eruption through the implant material will be compared to APCB, sham surgerized kittens that have had teeth extracted but no implants placed and untreated, control kittens with normal tooth eruption patterns. The kittens will be sacrificed at monthly intervals and analyzed radiographically and histologically. Histologic sectioning will be done on frozen mandibles in a cryostat microtome. The pilot study using 2 cats has shown that implantation of HA using the above model has retarded tooth development and eruption. The data obtained from this study will aid in treatment of cleft patients and also establish an animal model to study the interaction between CPC and tooth eruption.