SIGNAL ANALYSIS OF CEREBELLAR CORTICAL NEURONS

这里提出的研究将有助于我们理解 中枢神经系统如何控制肢体运动 更 具体来说，长期目标是提供可测试的 运动主要部分功能的工作假设 系统：小脑。 中提出的实验方法 该应用将是多进制的。 所载资料 由单个神经元件传输的电信号， 小脑皮层将与前肢运动相关 猴子的主题。 Parellel神经解剖追踪研究将 提供关于空间分布的信息 参与传入信息传递的途径， 小脑皮层 苔藓纤维的单神经元记录， 小脑的主要输入，提供了一种定义 从各种各样的信号传递到小脑的信号类型 来源于神经系统。 例如，为了成为 能够产生视觉引导的动作，视觉信息 需要与发送到肢体的运动指令相结合 肌肉产生运动。 小脑是一个质数 感觉和运动信号整合位点的候选者。 通过定义输入信号的信息内容， 将这些信号与小脑输出神经元的信号进行比较 在相同的行为任务中，我将评估 信号沿着通过小脑的信息流的路径。 这一基本信息有关的控制机制， 小脑是需要获得洞察小脑疾病 这会导致辨距障碍，一种运动障碍， 无法在空间和时间上产生目标导向的运动 没有反馈信息。

The studies proposed here will contribute to our understanding how the central nervous system controls limb movement. More specifically, the long term objective is to provide a testable working hypothesis for the function of a major part of the motor system: the cerebellum. The experimental approach proposed in this application will be multidisiplinary. Information contained in the electrical signals transmitted by individual neural elements in the cerebellar cortex will be correlated with forelimb movement of monkey subjects. Parellel neuroanatomical tracing studies will provide information concerning the spatial distribution of pathways involved in the transmission of afferent information to the cerebellar cortex. Single neuron recording of mossy fibers, the major input to the cerebellum, provides a means of defining the type of signals conveyed to the cerebellum from a variety of sources within the nervous system. For example, in order to be able to generate visually guided movements, visual information needs to be integrated with motor commands that are sent to limb muscles to produce movement. The cerebellum is a prime candidate for the site of integration of sensory and motor signals. By defining the information content of the input signals and comparing these signals with those of cerebellar output neurons during identical behavioral tasks, I will assess the processing of signals along the path of information flow through the cerebellum. This basic information concerning the control mechanisms of the cerebellum is needed to obtain insights into cerebellar diseases that lead to dysmetria, a movement disorder characterized by the inability to produce goal directed movements in space and time without feedback information.