MULTICHANNEL IMPLANTABLE SYSTEM FOR NEURAL CONTROL

这个项目的长期目标是恢复对马达的控制 中枢神经系统麻痹患者的感觉功能 通过使用使用电刺激的神经假体。 具体地说，用于控制手-臂功能的神经假体系统 为瘫痪患者提供高位颈椎脊髓 受伤，操作技能增强，从而改善他/她 在日常活动中的独立性。这个项目的具体目的是 开发一种集成的多通道植入式系统，当 临床上引入，将为用户提供简化的使用 系统和增强的功能功能。这将通过以下方式提供 使用植入的传感器进行控制和反馈，遥测 将这些信号经皮肤传输，激活的能力 更多的肌肉。 本项目的重点是开发先进的 植入式硬件系统及其评价。待开发的系统 将集成一个多通道遥测系统和一个多通道 带有植入式关节角度传感器的刺激器。单曲 遥测/模拟装置的设计和制造将使用LOW 功率微电子电路，可激活多达12块肌肉和 遥测多达三个关节角度传感器和两个肌电通道。 单个射频信号将被用来为系统供电，并 传递刺激和控制命令。遥测/刺激器装置 将密封在钛中，并用环氧树脂进行保形涂层 和弹性体，适合慢性植入。接缝角度 采用霍尔效应传感器的传感器、记录和刺激 电极和导线互连也将被制造出来。系统 将在体外和体内测试中进行评估，以确保适当 随着时间的推移而运作。加速的台架测试将对电子产品造成压力。 体外测试将连续提供可观察到的性能 受监控的环境。在狗模型上的活体测试将证明 植入系统的性能随时间的长期稳定性。在… 这些研究的完成，我们预计已经开发和完成 一种先进的神经假体应用系统的评价 适合人类使用。

The long term objective of this project is to restore control of motor and sensory function in individuals with central nervous system paralysis through the use of neural prostheses employing electrical stimulation. Specifically, neural prosthetic systems for control of hand-arm function provide the individual paralyzed with high cervical level spinal cord injury with enhanced manipulation skills, thus improving his/her independence in daily activities. The specific aim of this project is to develop an integrated multichannel implantable system which, when introduced clinically, will provide the user with simplified use of the system and enhanced functional capabilities. This will be provided through the use of implanted sensors for control and feedback, telemetry to transmit these signals transcutaneously, and the capacity for activating more muscles. The focus of this project is on the development of the advanced implantable hardware system and its evaluation. The system to be developed will integrate a multichannel telemetry system and a multichannel stimulator with an implanted joint angle sensor. The single telemetry/stimulation device will be designed and fabricated using low power microelectronic circuitry for activation of up to 12 muscles and telemetry of up to three joint angle sensors and two myoelectric channels. A single radiofrequency signal will be used to power the system and transmit stimulus and control commands. The telemetry/stimulator device will be hermetically sealed in titanium and conformally coated with epoxy and elastomer which are suitable for chronic implantation. Joint angle transducers employing Hall effect sensors, recording and stimulation electrodes, and lead interconnections also will be fabricated. The system will be evaluated in in vitro and in vivo testing to insure proper operation over time. Accelerated bench tests will stress the electronics. In vitro tests will provide observable performance in a continuously monitored environment. In vivo testing in a dog model will demonstrate the long term stability of performance of the implanted system over time. At the completion of these studies, we expect to have developed and completed the evaluation of an advanced system for neural prosthetic applications which is suitable for human application.