GORDON RESEARCH CONFERENCE ON HORMONAL CARCINOGENESIS

这次会议的目的是为权威人士提供一个论坛 积极参与各个学科的调查人员 定义荷尔蒙致癌研究的前沿。它是 重要的是，这些调查人员继续定期会面，以便 目的是讨论各自领域的最新发展， 分析当前研究的意义，探讨新的应对策略 未解决的问题，批判性地评估现有的理论，并发展 根据需要采用新的理论和方法。 1991年的会议将集中讨论规范 细胞的增殖、分化和转化。有参考价值 对于荷尔蒙相关肿瘤的风险特定组织， 会议将(1)讨论与以下方面相关的基本机制 乳腺癌和前列腺癌；(2)关键评估细胞的作用 肿瘤的分化缺陷；(3)考虑关键调控 激素调节生长的机制(正性和负性) 和正常细胞的分化，并考虑这些细胞中的像差是如何 基本机制可能与肿瘤的发生有因果关系；(4)研究 调节与类固醇生物合成有关的基因，代谢 共价中间体可能的致癌机制；(5) 明确雄激素、雌激素和孕激素的肿瘤潜能 发育和靶器官癌症的细胞生物学术语。主修 主题是：(1)生长因子和相互作用对细胞生长的控制 生长因子和激素之间的关系；(2)癌基因在 致癌；(3)生长控制中的间质-上皮相互作用 和致癌，以及(4)消极和积极的生长控制， 例如，抑制因子、抑癌基因或肿瘤抑制因子。 这次会议是正在进行的讨论荷尔蒙的主要会议。 以一种全面、综合的方式致癌。

The aim of this conference is to provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of research in hormonal carcinogenesis. It is important for such investigators to continue to meet regularly for the purpose of discussing the latest developments in their individual fields, to analyze the significance of current research, to discuss new tactics for unsolved problems, to critically evaluate current theories, and to develop new theories and approaches as needed. The 1991 conference will focus on the mechanisms which regulate the proliferation, differentiation and transformation of cells. With reference to the specific tissues at risk for hormonally associated neoplasms, the conference will (1) discuss the underlying mechanisms associated with breast and prostate cancer; (2) critically evaluate the role of cell differentiation defects in neoplasia; (3) consider key regulatory mechanisms (both positive and negative) by which hormones regulate growth and differentiation in normal cells, and consider how aberrations in these basic mechanisms might be causally related to neoplasia; (4) examine the regulation of genes involved with steroid biosynthesis, the metabolism of covalent intermediates as a possible mechanism of carcinogenesis; (5) define the neoplastic potential of androgens, estrogens and progestins in terms of the cell biology of development and cancer in target organs. Major themes are: (1) control of cell growth by growth factors and interactions between growth factors and hormones; (2) the role of oncogenes in carcinogenesis; (3) stromal-epithelial interactions during growth control and carcinogenesis, and (4) negative as well as positive growth controls, e.g., inhibitory factors, anti-oncogenes or tumor suppressors. This conference is the major ongoing meeting that discusses hormonal carcinogenesis in a comprehensive, integrated fashion.