PSYCHIATRIC IMPACT OF ANDROGEN-RELATED GENITAL DEFECTS

本建议书是一份小额赠款申请， 先天性器官畸形对心理健康的影响 （CASO）表明产前激素缺乏可能影响 大脑发育也是如此。 该研究旨在测试 假设的适当性和受试者招募的可行性， 随后更大规模研究的评估方法， 动力. 目标受试者是20名遗传男性，年龄6-10岁，出生于 小阴茎表明胎儿发育的慢性障碍 雄激素化，以及在男孩时期长大的人。 将有两个控制 组：（1）20名男性，出生时有轻微生殖器缺陷，正常大小 慢性产前雄激素缺乏症未被怀疑为 病因因素;这些受试者将与目标男孩匹配， 相关的人口变量。 (2)大约10个生殖器正常 目标受试者的兄弟属于同一年龄段。 社会心理（包括性别）和认知发展以及 精神影响将通过半结构化访谈进行评估， 问卷调查和心理测试与儿童，独立， 母亲 这将是第一个系统的对照研究， 标准工具的性别和精神发育的男孩， 先天性器官畸形，可归因于缺乏性器官发育 产前雄激素化 如果成功，研究将扩大到 青少年和成人患者。 长期目标是发展 经验验证的标准的性别分配的中间性 性心理管理的预防策略 儿童和青少年时期。

This proposal is an application for a Small Grant to initiate a project on the mental health effects of congenital abnormalities of the sex organs (CASO) indicative of prenatal hormone deficiences that are likely to affect brain development as well. The study is designed to test the appropriateness of hypotheses and feasibility of subject recruitment and of assessment methods for a subsequent larger study with more statistical power. Target subjects are 20 genetic males, age 6-10 years, who were born with a small penis which is indicative of chronic impairment of prenatal androgenization, and who were raised as boys. There will be two control groups: (1) 20 males born with minor genital defects and normal-sized penises in which a chronic prenatal androgen deficiency is not suspected as an etiologic factor; these subjects will be matched to the target boys on relevant demographic variables. (2) Approximately 10 genitally normal brothers of the target subjects that fall into the same age bracket. Psychosocial (including gender) and cognitive development as well as psychiatric impact will be assessed by means of semistructured interviews, questionnaires and psychometric tests with the child and, independently, the mother. This will be the first systematic controlled study using standard instruments of gender and psychiatric development in boys with congenital abnormalities of the sex organs attributable to deficient prenatal androgenization. If successful, the study will be expanded to adolescent and adult patients. The long-term goal is the development of empirically validated criteria for the sex of assignment of intersex newborns and for preventive strategies of psychosexual management during childhood and adolescence for these children.