CONDITIONED IMMUNOBIOLOGIC RESPONSES: IFN AND NK

本研究旨在探讨一个经典的权力和局限性， 诱导干扰素（IFN）滴度升高的条件反射模式 和增强自然杀伤（NK）细胞活性。 非条件 本研究的刺激（UCS）是Poly I：C注射， IFN滴度和NK活性（非条件反应）。 的 条件刺激（CS）是樟脑气味，一种对 任何已知的免疫参数 该实验室的初步研究表明，我们可以获得 增强NK活性使用这种条件反射范例，我们 我希望检查IFN滴度是否可以类似地调节。 此外，本发明还 我们将确定IFN水平条件性增强的限度， NK活性，我们将优化这些海拔的修改， CS/UCS配对试验计划，并最终确定 消除这些反应。 早在本世纪许多结果发表了从俄罗斯和 欧洲实验室展示了增强和抑制 多种特异性和非特异性免疫反应。 这些研究 遭受设计问题，在其他实验室的再现性是 不一致，因此这一领域的研究陷入失宠。 许多最近 调节免疫反应的努力导致了轻微的 抑制正在进行的抗体应答和移植物抗宿主 反应 这项研究的独特之处在于，我们成功地制作了一个 增强的NK细胞对CS的反应，这一结果可能被证明是一种免疫应答。 在没有抗原的情况下启动应答。 这项研究很重要，因为它探讨了心灵与 身体，抵抗疾病。 越来越明显的是， 许多疾病是多因素的，心理社会方面可能起作用， 在这些疾病的病因学中起重要作用。

This study proposes to investigate the power and limitations of a classical conditioning paradigm in eliciting an elevation in interferon (IFN) titer and an enhancement of Natural Killer (NK) cell activity. The unconditioned stimulus (UCS) for this study is a Poly I:C injection, which will elevate both IFN titers and NK activity (the unconditioned response). The conditioned stimulus (CS) is camphor smell, a stimulus without effect on any known immune parameter. Preliminary studies from this laboratory have shown that we can obtain an enhancement of the NK activity using this conditioning paradigm, and we wish to examine whether IFN titers can be similarly conditioned. Further, we will determine the limits of conditioned enhancement of IFN levels and NK activity, we will optimize these elevations by modification of the schedule of CS/UCS pairing trials, and finally determine the pattern for extinction of these responses. Earlier in this century many results were published from Russian and European laboratories demonstrating both enhancement and suppression of a variety of specific and non-specific immune responses. These studies suffered from design problems, and reproducibility in other labs was inconsistent, thus this area of research fell into disfavor. Many recent efforts at conditioning immune responses have resulted in a slight suppression of both ongoing antibody responses and a graft-vs-host response. This study is unique in that we have successfully produced an enhanced NK cell response to a CS, a result which may prove to be an initiated response in the absence of antigen. This study is important because it explores the connection between mind and body, and resistance to disease. It has become increasingly apparent that many diseases are multifactoral, and psychosocial aspects may play an important role in the etiology of these diseases.