PERIODONTITIS IN STRESSED ALZHEIMER CAREGIVERS

尽管有一致的发现表明，压力性生活事件会增加 疾病，心理社会压力在牙周病病因学中的作用 疾病仍然知之甚少。 此前的报道称， 轶事性质或心理社会压力概念化不足 或牙周病的临床测量不佳。 然而此时， 良好表征的慢性应激人类模型，沿着充分 牙周炎的敏感指标，使这方面的可行性研究。 该项目旨在作为一项初步调查，以评估 心理社会应激与牙周炎的发生有一定关系。 使用 横断面设计，我们将比较临床和实验室结果 从一组老年痴呆症护理人员中诊断出一个匹配的比较 组 患有阿尔茨海默病的家庭成员的长期照顾者 被证明经历慢性压力，通常在一个年龄组， 容易患慢性成人牙周炎。 此外，该集团还 被证明有免疫缺陷，患病风险增加。 因此，阿尔茨海默氏症照顾者可能是一个很好的模型， 强调牙周炎的研究。 第一个项目的目标是确定慢性压力阿尔茨海默病是否 护理者比匹配的对照组有更严重的牙周炎。 比较探诊深度、临床附着水平、出血指数和 龈沟液中PGE 2和β-葡萄糖醛酸酶的浓度 组之间将进行。 第二个项目目标是确定， 如果有的话，选择的变量是压力和 牙周炎 全血细胞计数，唾液免疫球蛋白，社会 支持、牙菌斑和中性粒细胞功能（趋化性、超氧化物 产生、吞噬和杀伤）将与临床 调查结果。 除了评估慢性应激模型的实用性， 心理社会应激与牙周病关系 将提供有关个人口腔健康的流行病学信息 他们为患有阿尔茨海默病的家庭成员提供长期护理。

Despite consistent findings that stressful life events increase the risk of illness, the role of psychosocial stress in the etiology of periodontal disease remains poorly understood. Past reports have earlier been anecdotal in nature or inadequate conceptualizations of psychosocial stress or poor clinical measures of periodontal disease. At this time however, well characterized human models of chronic stress, along with sufficiently sensitive indicators of periodontitis, make feasible studies in this area. The project is designed as a preliminary investigation to assess whether a relationship exists between psychosocial stress and periodontitis. Using a cross-sectional design, we will compare clinical and laboratory findings from a group of Alzheimer caregivers to diagnose of a matched comparison group. Long term caregivers of family members with Alzheimer Disease have been shown to undergo chronic stress, and are usually in an age group which is susceptible to chronic adult periodontitis. In addition, this group has been shown to have immune deficits and to be at increased risk for illness. Consequently, Alzheimer caregivers may be an excellent model of human stress in which to study periodontitis. The first project aim is to determine if chronically stressed Alzheimer caregivers have greater periodontitis than a matched comparison group. Comparison of probing depth, clinical attachment level, bleeding index, and gingival crevicular fluid concentrations of PGE2 and b-glucuronidase between groups will be made. The second project aim is to determine which, if any, of selected variables are potential mediators between stress and periodontitis. Complete blood counts, salivary immunoglobulins, social support, dental plaque, and neutrophil function (chemotaxis, superoxide production, phagocytosis and killing) will be related to the clinical findings. In addition to assessing the utility of a chronic stress model to explore the relationship of psychosocial stress to periodontal disease, this study will provide epidemiologic information about the oral health of individuals who provide long-term care to family members with Alzheimer Disease.