THE ACUTE PHASE AND IMMUNE RESPONSES: A NEW CYTOKINE

在过去的一年里，人们清楚地看到，蛋白质被不同地描述为 “干扰素-β2”、“肝细胞刺激因子”、“B细胞刺激因子” 因子-2“、”杂交瘤/浆细胞瘤生长因子“、”26-kDz蛋白“和 “白细胞介素6”是由同一基因衍生而来。该计划的目的是 拟议在纽约市举行的为期3天的会议(1988年12月12日至14日)将带来 到目前为止，来自不同学科的调查人员已经 从个体角度研究了这些多肽。这次会议 将尝试讨论和整理关于 人和啮齿动物的遗传学、结构、调节和功能 这个细胞因子家族的成员。分泌蛋白(19~30 kDa) 已有报道从人干扰素-β2/hsf/IL-6基因中介导了 肝细胞“急性期”血浆蛋白分泌的主要变化， 诱导成纤维细胞处于抗病毒状态，促进小鼠增殖 杂交瘤细胞，最近促进了人B细胞的增殖 经EB病毒转化，通过增强免疫球蛋白的分泌 人B细胞系对人和小鼠的增殖作用 胸腺细胞和T细胞(尤其是已知耗尽的CD4+细胞 在艾滋病中)，促进造血祖细胞的集落形成和 调节对组织损伤的热原反应。这款多功能 细胞因子家族已成为宿主反应的主要组成部分 有毒物质，组织损伤和创伤。干扰素-β2/hsf/IL-6基因是 在成纤维细胞、单核细胞、角质形成细胞、其他上皮细胞和 间充质细胞和内皮细胞。通常，干扰素-1的表达 多种不同细胞类型中的Beta2/HSF/IL-6被其他 炎性细胞因子，如白介素1，肿瘤坏死因子， 淋巴毒素、血小板衍生生长因子、其他干扰素 细菌产物，如内毒素，由dsRNA，如聚(I).聚(C)，和 由几种含有RNA和DNA的急性传染病病毒(仙台， 脑心肌炎、水泡性口炎、流感、伪狂犬病和 腺病毒)。我们建议将不同领域的调查人员聚集在一起 最近一直在研究干扰素-β2/人类SF/白介素6的学科 好几年了。这样一个跨学科的会议将是一种催化剂 一个新兴研究领域的发展，以及出版 其会议纪要(刊登在纽约亚卡德的年鉴上)。SCI.)很可能成为一种 这是该领域发展的重要里程碑。也许它可以允许 这一领域的调查人员，无论是现在还是未来，都会说同样的话。

It has become clear in the last year that proteins variously described as "interferon-beta2", "hepatocyte stimulating factor", "B cell stimulatory factor-2", "hybridoma/plasmacytoma growth factor", "26-kDz protein", and "interleukin-6" are derived form the same gene. The purpose of the proposed 3-day conference in New York City (Dec 12-14, 1988) is to bring together investigators from different disciplines who, until now, have studied these polypeptides from individual perspectives. This conference will attempt to discuss and collate information on all aspects of the genetics, structure, regulation and function of the human and rodent members of this cytokine family. Secretory proteins (19 to 30 kDa) derived from the human IFN-beta2/HSF/IL-6 gene have been reported to mediate the major alterations in "acute phase" plasma protein secretion by hepatocytes, elicit an antiviral state in fibroblasts, enhance proliferation of murine hybridoma cells, enhance proliferation of human B cells recently transformed by Epstein-Barr virus, enhance secretion of immunoglobulins by human B cell lines, contribute to the proliferation of human and murine thymocytes and T cells (in particular the CD4+ cells known to be depleted in AIDS), enhance colony formation by hematopoietic progenitor cells and mediate a pyrogenic response to tissue damage. This multifunctional cytokine family has emerged as a major component in the host response to noxious agents, tissue damage and trauma. The IFN-beta2/HSF/IL-6 gene is expressed in fibroblasts, monocytes, keratinocytes, other epithelial and mesenchymal cells and in endothelial cells. Typically, expression of IFN- beta2/HSF/IL-6 in a variety of different cell types is enhanced by other inflammatory cytokines such as interleukin-1, tumor necrosis factor, lymphotoxin, platelet-derived growth factor, other interferons, by bacterial products such as endotoxin, by dsRNA such as poly(I).poly(C), and by several RNA-and DNA-containing acute infectious viruses (Sendai, encephalomyocarditis, vesicular stomatitis, influenza, pseudorabies and adenoviruses). We propose to bring together investigators in different disciplines who have been working with IFN-beta2/HSF/IL-6 for the last several years. Such an interdisciplinary conference would be a catalyst to the development of a newly emerging area of research, and the publication of its proceedings (in Annals, NY Acad. Sci.) is likely to become an important landmark in the development of this field. Perhaps it may allow investigators in this area, present and future, to speak the same language.