NEURAL TRANSPLANTATION AND MODELS OF AGING AND DEMENTIA

这次纽约科学院研讨会的支持者以前见过面， 在隆德举行的国际研讨会之后选择大脑的这些方面 其中最值得关注的是移植。两个主题， 看似在一个大陆的两端，之所以被选中，是因为(1) 新数据的出现；(2)需要相互交流技术和思想 从事基础和应用研究的科学家；以及(3)对 神经移植技术在临床医学中的应用进展。这个 我们选择的具体主题可以分为两个大的领域： 成人大脑对供体神经细胞和 组织；以及衰老、痴呆和神经退行性疾病的模型 灵长类和次灵长类的大脑。 本提案从细胞的三个核心主题开始。 供体细胞与宿主脑整合的机制：(1) 神经元和神经胶质细胞的相互作用，(2)营养物质的产生 移植后的物质，以及(3)特定的 细胞。预计潜在的细胞和分子事件 神经元、神经胶质细胞和内皮细胞之间的相互作用以及 对最佳结合成人宿主和捐赠者的程序的重要见解 将对中枢神经系统细胞进行彻底的讨论。 拟议专题讨论会的后半部分专门讨论衰老模型， 痴呆症，阿尔茨海默氏症，帕金森氏症和亨廷顿舞蹈症。这个 第一次会议将处理本地化引起的锥体外系疾病 6-羟基多巴胺和鹅膏油酸的损伤。第二个交易日 伴随着衰老和痴呆症。本次会议提出了一些令人振奋的发现 通过神经元移植和其他方法逆转与年龄相关的缺陷 皮质移植对改善认知功能障碍的作用 是由大脑损伤造成的。最后一次会议将直接讨论 人类和灵长类动物脑移植的重要课题。非常 将介绍关于MPTP损伤猴子的最新研究和进展 关于瑞典进行的人体研究的报告。

The proponents of this New York Academy of Science symposium met before and after the International Symposium in Lund to select those aspects of brain transplantation which deserved the greatest attention. Two topics, seemingly at either end of a continum, were chosen because of the (1) emergence of new data; (2) need for exchange of techniques and ideas among scientist engaged in basic and applied research; and (3) importance to the progress of neuronal transplantation procedures in clinical medicine. The specific topics selected by us can be grouped into two general areas: molecular and cellular responses in adult brain to donor neural cells and tissues; and models of aging, dementia, and neurodegenerative diseases in primate and subprimate brain. The present proposal begins with three topics central to cellular mechanisms involved in the integration of donor cells with host brain: (1) Interaction of neurons and glial cells, (2) production of trophic substances following transplantation, and (3) transplantation of specific cells. It is expected that the cellular and molecular events underlying the interactions between neurons, glial, and endothelial cells and important insights into procedures to best integrate adult host and donor CNS cells will be thoroughly discussed. The second half of the proposed symposium is devoted to models of aging, dementia, Alzheimer's Disease, Parkinsonism and Huntington's Chorea. The first session will deal with extrapyramidal disorders produced by localized lesions with 6-OH-dopamine and ibotenic acid. The second session deals with aging and dementia. This session presents exciting findings on reversal of age-related deficits by neuronal transplantation and also on the effects of cortical transplants on improving cognitive deficits produced by brain damage. The final session will deal directly with the important topic of brain transplantation into humans and primates. Very recent studies will be presented on MPTP lesioned monkeys and a progress report on the human studies performed in Sweden.