FOURTH INTERNATIONAL WORKSHOP ON MOUSE GENOME MAPPING

这项提案要求支持一系列国际会议中的第四项 小鼠基因组作图促进交流、整合的工作坊 以及遗传信息在科学家中的分布 小鼠基因组。美国国立卫生研究院基因组办公室主办了一次领先的 1989年11月，普林斯顿大学小鼠基因组图谱的研究人员 大学为绘制小鼠基因组图定义了一套共同的目标。 从那次会议起草了一份报告，讨论了遗传和生理问题 绘制小鼠基因组图，启动集中数量的基因组 排序、信息学问题和鼠标的特殊性质 促进基因组图谱工作的遗传资源。这次会议 在本申请中提出的将有助于建立更多 正式的工作组和委员会，以确保继续 合作努力，将信息和数据库开发整合到 以国际为基础。这次会议的目标是(1)讨论 并评估普林斯顿报告中概述的目标；(2)整合 将基因组图谱信息转化为复合的遗传和物理图谱； (3)评估物理地图信息，共享地图资源； (4)考察大规模DNA测序的现状 技术；(5)评估小鼠基因组数据库及其可访问性 和管理；以及(6)正式确定国际小鼠基因组 将主办未来研讨会并促进互动的组织 在老鼠基因组工作的研究人员中。

This proposal requests support for the 4th in a series of International Workshops on Mouse Genome Mapping to stimulate the exchange, integration and distribution of genetic information among scientists analyzing the mouse genome. The Genome Office of NIH sponsored a meeting of leading investigators in mouse genome mapping in November, 1989 at Princeton University to define a set of common goals for mapping of the mouse genome. A report was drafted from that meeting that addressed genetic and physical mapping of the mouse genome, the initiation of focused amounts of genome sequencing, the problem of informatics and the special nature of mouse genetic resources that facilitate the genome mapping work. The meeting proposed in this application will assist in the establishment of more formalized working groups and committees to insure the continuation of cooperative efforts for integrating information and database development on an international basis. The goals of this meeting will be to (1) discuss and evaluate the goals outlined in the Princeton report; (2) to integrate the genome mapping information into composite genetic and physical maps; (3) to evaluate physical mapping information and share mapping resources; (4) to examine the current status of large scale DNA sequencing technologies; (5) to evaluate mouse genome data bases, their accessibility and management; and (6) to formalize an international mouse genome organization that will sponsor future workshops and promote interaction among investigators in the mouse genome effort.