GORDON RESEARCH CONFERENCE ON LYSOSOMES

关于溶酶体的戈登会议将提供一个非正式论坛 以讨论当前的进展和细胞的新方向 以及细胞内细胞器的分子生物学。特价 将关注下列病理生理过程 基于亚细胞结构和功能的异常。 课程将致力于研究细胞分类的机制 新合成的蛋白质；囊泡运输和马达- 驱动细胞内囊泡运动的蛋白质；细胞器和 溶酶体的生物发生及其胞内研究的新方向 靶向受体介导的内吞作用及其重构 沿着内吞途径的融合事件；抗原和蛋白质 免疫细胞的处理以及某些特定的机制 微生物逃避免疫破坏；选择蛋白质周转 溶酶体和胞浆蛋白水解酶与蛋白质运动 在这两个隔间之间。最后，将举行一次会议 组织了关于我们对溶酶体的理解的进展 储藏病，特别强调涉及的机理 以及利用转基因动物研究酶 替代疗法。我们将特别努力包括 参与该计划的年轻调查人员，并鼓励 个人将参加计划中的两个海报会议之一 下午的时间。此外，年轻的调查人员将被 从海报会议中挑选出来，向 在每一次会议中聚集成一组。这应该允许 最大限度地传播新数据，并应允许年轻人 工人与补充者进行重要联系 纪律。 我们要求细胞生物学对此申请进行审查 研究组，这是一个在他的领域拥有特殊专业知识的小组。我们 我也希望这项建议能在以下方面得到考虑 除了NIGMS之外，还有几个NIH研究所。参与其中的 溶酶体和其他细胞内间隔涉及 沙门氏菌的分泌、加工和内吞作用 各种疾病状态将在总体上成为 那次会议。提出的计划的多样性应该允许 让具有不同研究的个人广泛参与 兴趣。

The Gordon Conference on Lysosomes will provide an informal forum for discussion of current advances and new directions in the cell and molecular biology of intracellular organelles. Special attention will be paid to pathophysiologic processes which are based on aberrations in subcellular structure and function. Sessions will be devoted to the mechanisms by which cells sort newly synthesized proteins; vesicular transport and the motor- proteins that drive vesicle movement in cells; organelle and lysosome biogenesis and new directions in intracellular targeting' receptor-mediated endocytosis and the reconstitution of fusion events along the endocytic pathway; antigen and protein processing by immune cells and the mechanisms by which certain microbes evade immune destruction; selection protein turnover by lysosomal and cytoplasmic proteases and the movement of proteins between these two compartments. Finally, a session will be organized on the progress in our understanding of lysosomal storage disease with special emphasis on the mechanisms involved and the use of transgenic animals for studies of enzyme replacement therapy. We will make special effort to include young investigators on the program and to encourage such individuals to participate in one of two poster sessions planned for the afternoons. ADditionally, young investigators will be selected from the poster session to present their work to the assembled group in each of the sessions. This should allow for the maximum dissemination of new data and should allow young workers to make important contacts with those in complementary disciplines. We request that this application be reviewed by the Cell Biology Study Section, a group with special expertise int his area. We also would like this proposal considered for partial funding by several NIH institutes in addition to NIGMS. The involvement of lysosomes and other intracellular compartments involving secretion, processing and endocytosis in the pathophysiology of a variety of disease states will be a significant overall part of the meeting. The diversity of the program presented should allow for wide participation of individuals with diverse research interests.