GDP AND GTP BINDING TO RAB 5

GDP 和 GTP 与 RAB 5 结合

• 批准号: 7721551
• 负责人: PHILIP D STAHL
• 金额: $ 0.71万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721551
• 关键词: Animals; Binding; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Guanosine Diphosphate; Guanosine Triphosphate; Institution; Knockout Mice; Protein Isoforms; Proteins; Research; Research Personnel; Resources; Sequence Homology; Signaling Protein; Source; Structure; United States National Institutes of Health; mouse Gdi2 protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rab5 is a signaling protein that exists in three isoforms. All forms (Rab5 A, Rab5B, Rab5 C) have significant sequence homology and similar structures. It was once believed that these proteins were redundant, however recent studies with knock out mice have demonstrated that each isoform is required healthy animals. A conformational change occurs upon binding GDP or GTP.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 Rab5是一种存在于三种同工型中的信号蛋白。 所有形式（rab5 a， Rab5b，Rab5 c）具有显着的序列同源性和相似的结构。 它 曾经认为这些蛋白质是多余的，但是最近的研究 用敲除小鼠证明每个同工型都需要健康 动物。结合GDP或GTP发生构象变化。